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ACL Reconstructed Knee: qMRI and Biomechanical Modeling

Award Number: R01HD087459
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2016
PERIOD OF PERFORMANCE END DATE: 01/31/2022

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ACL Reconstructed Knee: qMRI and Biomechanical Modeling - DESCRIPTION (provided by applicant): There is an established relationship between anterior cruciate ligament (ACL) injury and the development of osteoarthritis (OA). Following injury and surgical reconstruction, OA is reported in the medial compartment of the involved knee in 30 to 60% of patients within five to eight years. While increased muscle co-contraction often occurs in the unloaded knee, more detailed biomechanical analysis from our lab has shown that the involved knee undergoes unloading in the medial compartment. That is, the compressive joint contact force in the medial compartment of the involved knee is less than in the uninvolved knee during gait. The unloading is observed immediately after injury and is still quite pronounced at six months, but loading returns to normal two years after ACL reconstruction. However, differences in loading between impaired and unimpaired limbs at six months post-surgery is correlated with OA development 5 years post-surgery. In this study, we will examine the biomechanical and biochemical basis for this by studying people at 3 months, 6 months and 2 years following ACL reconstruction. In the first aim, we will explore the biomechanical basis of this unloading using EMG and gait analysis techniques, couple with the use of a biomechanical model that will allow joint contact force estimation. In Aim 2, quantitative magnetic resonance imaging of the knee will be used to discern biochemical changes in the cartilage during the post-surgery period (same three time points). T1ρ and T2 relaxation time quantification (indicative of glycosaminoglycan loss and decreased collagen matrix organization) will be performed for each limb. In Aim 3, we will examine the effect of knee loading differences on knee cartilage stress distribution, using a finite element model. This will enable us to determine how the loading and biochemical changes influence the pressure in the cartilage. We believe that these aims will enable us to understand the mechanisms governing knee unloading following ACL reconstruction and will enable us to make recommendations for clinical treatment paths to avoid subsequent OA development in this population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$55,361 )
2022	2020	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Child Health and Human Development Extramural Research	000	5	9/23/2022	NON-COMPETING CONTINUATION	-$55,361
														Subtotal = -$55,361

Issue Date FY: 2020 ( Subtotal = $352,311 )
2020	2020	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Child Health and Human Development Extramural Research	000	5	2/6/2020	NON-COMPETING CONTINUATION	$352,311
														Subtotal = $352,311

Issue Date FY: 2019 ( Subtotal = $351,016 )
2019	2019	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Child Health and Human Development Extramural Research	000	4	1/28/2019	NON-COMPETING CONTINUATION	$351,016
														Subtotal = $351,016

Issue Date FY: 2018 ( Subtotal = $352,646 )
2018	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Child Health and Human Development Extramural Research	000	3	2/13/2018	NON-COMPETING CONTINUATION	$317,381
2018	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Child Health and Human Development Extramural Research	001	3	5/1/2018	NON-COMPETING CONTINUATION	$35,265
														Subtotal = $352,646

Issue Date FY: 2017 ( Subtotal = $353,964 )
2017	2017	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Child Health and Human Development Extramural Research	001	2	6/20/2017	NON-COMPETING CONTINUATION	$35,396
2017	2017	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Child Health and Human Development Extramural Research	000	2	1/13/2017	NON-COMPETING CONTINUATION	$318,568
														Subtotal = $353,964

Issue Date FY: 2016 ( Subtotal = $357,234 )
2016	2016	UNIVERSITY OF DELAWARE	210 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Child Health and Human Development Extramural Research	000	1	3/30/2016	NEW	$357,234
														Subtotal = $357,234

Grand Total All Awards = $1,711,810

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ACL Reconstructed Knee: qMRI and Biomechanical Modeling

Award Number: R01HD087459

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2016

PERIOD OF PERFORMANCE END DATE: 01/31/2022

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