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Genetic and Environmental Origins of the Development of Pain in Children

Award Number: R01HD086085
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2016
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Genetic and Environmental Origins of the Development of Pain in Children - Project Summary Pediatric chronic pain is a common but understudied health problem, with prevalence increasing from childhood to adolescence, particularly among girls. Moreover, prevalence rates have increased over the past 20 years for unknown reasons. Despite the high prevalence and enduring impact, we know little about its etiology and developmental progression. The literature documents associations between exposure to early adversity and chronic pain among adults, but little is known about the early developmental time course, key mechanisms, and social resilience that can mitigate risk in youth. Critical questions need to be addressed before efforts at prevention and intervention can have maximum impact. To that end, the proposed competing continuation project focuses on four aims: identify the genetic and environmental influences on growth in pain across childhood and adolescence (Aim1); examine the role of stress exposure in the development of children's chronic pain (Aim 2); and evaluate two potential mechanisms linking stress and pain, problems with emotion regulation (Aim 3), and epigenetics (Aim 4). Under a recalibration model, we also explore social resilience in adolescence as a buffer of these risk processes. To accomplish our aims, we propose to conduct intensive longitudinal follow-up assessments (at 14, 15, and 16 years of age) of a birth-records-based community sample of 350 pairs of twins who are diverse in ethnicity and socioeconomic status. Stress, emotion regulation, and recurring pain during early and middle childhood have already been well characterized. Assessments during adolescence will take a multi-method approach that includes clinical and diary assessments of pain frequency, intensity, duration; objective, diary, and questionnaire assessments of emotion regulation, stress, and social resilience; and objective assessments of epigenetics. Our genetically informed developmental approach to understanding the etiology and mechanisms of pain in youth is critical to determining when benign chronic pain is clinically significant and identifying key targets for intervention efforts to prevent the development of and promote recovery from chronic pain among youth.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $616,403 )
2025	2025	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	9	2/28/2025	NON-COMPETING CONTINUATION	$554,765
2025	2025	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	001	9	4/22/2025	NON-COMPETING CONTINUATION	$61,638
														Subtotal = $616,403

Issue Date FY: 2024 ( Subtotal = $620,734 )
2024	2024	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	8	2/21/2024	NON-COMPETING CONTINUATION	$564,305
2024	2024	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	001	8	5/7/2024	NON-COMPETING CONTINUATION	$56,429
2024	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	002	5	9/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $620,734

Issue Date FY: 2023 ( Subtotal = $642,053 )
2023	2023	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	7	3/1/2023	NON-COMPETING CONTINUATION	$642,053
														Subtotal = $642,053

Issue Date FY: 2022 ( Subtotal = $633,050 )
2022	2022	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	001	6	3/10/2022	COMPETING CONTINUATION	$633,050
2022	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	5	2/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $633,050

Issue Date FY: 2020 ( Subtotal = $538,596 )
2020	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	5	7/14/2020	NON-COMPETING CONTINUATION	$538,596
														Subtotal = $538,596

Issue Date FY: 2019 ( Subtotal = $564,301 )
2019	2019	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	4	7/22/2019	NON-COMPETING CONTINUATION	$564,301
														Subtotal = $564,301

Issue Date FY: 2018 ( Subtotal = $584,080 )
2018	2018	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	3	7/10/2018	NON-COMPETING CONTINUATION	$584,080
														Subtotal = $584,080

Issue Date FY: 2017 ( Subtotal = $599,249 )
2017	2017	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	2	6/30/2017	NON-COMPETING CONTINUATION	$599,249
														Subtotal = $599,249

Issue Date FY: 2016 ( Subtotal = $615,366 )
2016	2016	ARIZONA STATE UNIVERSITY	P.O. BOX 873503	TEMPE	AZ	85287	MARICOPA	USA	Child Health and Human Development Extramural Research	000	1	7/28/2016	NEW	$615,366
														Subtotal = $615,366

Grand Total All Awards = $5,413,832

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Genetic and Environmental Origins of the Development of Pain in Children

Award Number: R01HD086085

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2016

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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