Tuesday, September 16, 2025 9/16/2025

Improved function performance in individuals with transradial limb difference using cloud based health system and deep learning

Award Number: R01HD081525
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2014
PERIOD OF PERFORMANCE END DATE: 08/31/2028

Group Awards By:

View Award Description

Improved function performance in individuals with transradial limb difference using cloud based health system and deep learning - PROJECT SUMMARY Transradial amputation is the most common type of major upper limb absence and causes substantial disability. On average, over 1,700 Americans receive a new upper limb amputation (wrist disarticulation level or higher) each year. Over 75% of these individuals are between the ages of 18 and 64 and therefore desire to continue being active. Prosthetic devices are accepted treatment options for upper limb amputation to restore the functional capabilities of the lost arm. However, despite impressive improvements in the last decade, current prosthetic device capabilities still fall far below the functionality of the natural arm and hand, something that contributes to high device rejection rates. Based on our prior study upon which this proposed renewal builds, we identified two important causes for this lack of functionality: signal detection losses caused by physical issues such as intermittent electrode contact and broken lead wires, and user issues such as not making appropriate and distinct muscle contractions when recalibrating the prosthetic device. This study will address these issues through the application of novel technology: deep learning combined with data augmentation to automatically compensate for EMG signal deterioration/loss. This innovative technology will be applied and tested in the following aim. A linear discriminate analysis pattern recognition prosthetic controller will be compared to a prosthetic controller supplemented with deep learning to see which performs better when noise is introduced, as determined by functional and virtual outcomes testing. The primary outcome will be the total number of blocks moved before participants are unable to continue when noise is added to the system. Secondary outcomes include standardized clinical outcome measures such as the Southampton Hand Assessment Procedure, Clothespin Relocation Test, and Jebsen-Taylor Hand Function Test. This work will (i) formulate an effective deep learning method of compensating for control system signal detection issues. By mitigating signal detection issues, this work will provide significant improvements in prosthesis control/function, laying the groundwork for more intuitively controlled prosthetics for individuals with upper limb absence.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,978,028 )
2025	2025	REHABILITATION INSTITUTE OF CHICAGO	355 E ERIE ST	CHICAGO	IL	60611	COOK	USA	Child Health and Human Development Extramural Research	000	6	8/20/2025	COMPETING CONTINUATION	$1,978,028
														Subtotal = $1,978,028

Issue Date FY: 2021 ( Subtotal = -$7,314 )
2021	2018	REHABILITATION INSTITUTE OF CHICAGO	355 EAST ERIE	CHICAGO	IL	60611	COOK	USA	Child Health and Human Development Extramural Research	000	5	6/27/2021	NON-COMPETING CONTINUATION	-$7,314
														Subtotal = -$7,314

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	REHABILITATION INSTITUTE OF CHICAGO	355 EAST ERIE	CHICAGO	IL	60611	COOK	USA	Child Health and Human Development Extramural Research	000	5	7/12/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $607,321 )
2018	2018	REHABILITATION INSTITUTE OF CHICAGO	355 EAST ERIE	CHICAGO	IL	60611	COOK	USA	Child Health and Human Development Extramural Research	000	5	6/27/2018	NON-COMPETING CONTINUATION	$607,321
														Subtotal = $607,321

Issue Date FY: 2017 ( Subtotal = $695,697 )
2017	2017	REHABILITATION INSTITUTE OF CHICAGO	355 EAST ERIE	CHICAGO	IL	60611	COOK	USA	Child Health and Human Development Extramural Research	000	4	7/20/2017	NON-COMPETING CONTINUATION	$695,697
														Subtotal = $695,697

Issue Date FY: 2016 ( Subtotal = $705,021 )
2016	2016	REHABILITATION INSTITUTE OF CHICAGO	345 E SUPERIOR ST	CHICAGO	IL	60611	COOK	USA	Child Health and Human Development Extramural Research	000	3	7/25/2016	NON-COMPETING CONTINUATION	$705,021
														Subtotal = $705,021

Issue Date FY: 2015 ( Subtotal = $686,141 )
2015	2015	REHABILITATION INSTITUTE OF CHICAGO	345 E SUPERIOR ST	CHICAGO	IL	60611	COOK	USA	Child Health and Human Development Extramural Research	000	2	6/15/2015	NON-COMPETING CONTINUATION	$686,141
														Subtotal = $686,141

Issue Date FY: 2014 ( Subtotal = $595,012 )
2014	2014	REHABILITATION INSTITUTE OF CHICAGO	345 E SUPERIOR ST	CHICAGO	IL	60611	COOK	USA	Child Health and Human Development Extramural Research	000	1	9/18/2014	NEW	$595,012
														Subtotal = $595,012

Grand Total All Awards = $5,259,906

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Improved function performance in individuals with transradial limb difference using cloud based health system and deep learning

Award Number: R01HD081525

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2014

PERIOD OF PERFORMANCE END DATE: 08/31/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer