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Social and Genetic Contributions to Children's Sleep, Health and Functioning

Award Number: R01HD079520
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2015
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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Social and Genetic Contributions to Children's Sleep, Health and Functioning - Project Summary With our ethnically and socioeconomically diverse longitudinal twin study, in this competing continuation we aim to understand the genetic and environmental mechanisms linking sleep and physical health across pubertal development. We also elucidate mechanisms accounting for longitudinal associations between these health processes and both mental health and inflammation in adolescence. Further, we examine a key proximal sociocultural process - daily media use - which is pervasive in the everyday lives of adolescents. With inflammation and mental health problems on the rise among youth, it is imperative that we utilize a well- powered (N=700 twin youth), representative (recruited from birth records), genetically-informed (twin study), longitudinal (followed since infancy with proposed assessments at 12 and 14 years) design to identify risk and resilience processes across the major transition from childhood to adolescence. To date, our results suggest that sleep is linked with cognition and health for genetic rather than environmental reasons (see C1), suggesting that third variables are involved that may vary by development (puberty). More specifically, we add two follow ups of a diverse twin sample recruited from birth records and assessed at 1, 2, 5, 8, 9, 10 & 11 years (N=700 youth; Arizona Twin Project). At 12 years, we add new assessments of the environment (e.g. media use) and extend our objective measures of sleep and health (aerobic, muscular, adiposity, physiology). At age 14, we add new outcome assessments (inflammatory biomarkers, mental health). Under Aim 1, we use parallel process growth models from childhood into adolescence to determine direction of effects among puberty, sleep, and multiple indicators of health. Under Aim 2, we dynamically extend this work by using intercepts and growth parameters from the parallel process growth models outlined in Aim 1 to predict inflammation and mental health at age 14. Under Aim 3, we examine the genetic and environmental overlap among puberty, sleep, and health and pinpoint aspects of the environment that play a role in health. Such an examination is critical as our work has shown that common risk factors and health are often associated for genetic as opposed to environmental reasons which can shift the focus of potential interventions. Under Aim 4, we disentangle genetic and environmental contributions to associations between daily sociocultural contexts, sleep and health. The proposed study builds on existing collaborations with complementary expertise. The project is notable as it is the only twin sample of youth to obtain longitudinal objective sleep, health, and sociocultural context data, for its developmental cultural and genetic approach that uncovers gene-environment interplay, measurement of physiological and inflammation biomarkers, and examination of proximal sociocultural processes including objective media use in adolescence. Combining these design features exponentially increases the scientific contribution, elucidating processes that support preventive intervention efforts.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $582,137 )
2025	2025	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	001	10	4/25/2025	NON-COMPETING CONTINUATION	$58,213
2025	2025	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	10	12/12/2024	NON-COMPETING CONTINUATION	$523,924
														Subtotal = $582,137

Issue Date FY: 2024 ( Subtotal = $596,650 )
2024	2024	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	003	9	5/2/2024	NON-COMPETING CONTINUATION	$54,243
2024	2024	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	002	9	4/25/2024	NON-COMPETING CONTINUATION	$0
2024	2024	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	001	9	3/6/2024	NON-COMPETING CONTINUATION	$0
2024	2024	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	9	11/30/2023	NON-COMPETING CONTINUATION	$542,407
														Subtotal = $596,650

Issue Date FY: 2023 ( Subtotal = $621,946 )
2023	2023	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	8	3/16/2023	NON-COMPETING CONTINUATION	$621,946
2023	2023	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	005	8	8/17/2023	NON-COMPETING CONTINUATION	$0
2023	2021	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	004	6	4/7/2023	COMPETING CONTINUATION	-$111,339
2023	2021	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	002	6	3/21/2023	COMPETING CONTINUATION	-$14,478
2023	2019	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	003	5	4/7/2023	NON-COMPETING CONTINUATION	$111,339
2023	2019	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	001	5	3/21/2023	NON-COMPETING CONTINUATION	$14,478
														Subtotal = $621,946

Issue Date FY: 2022 ( Subtotal = $637,523 )
2022	2022	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	003	7	4/25/2022	NON-COMPETING CONTINUATION	$63,752
2022	2022	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	002	7	12/3/2021	NON-COMPETING CONTINUATION	$573,771
2022	2021	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	001	6	11/24/2021	COMPETING CONTINUATION	$125,817
2022	2019	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	5	11/24/2021	NON-COMPETING CONTINUATION	-$125,817
														Subtotal = $637,523

Issue Date FY: 2021 ( Subtotal = $656,436 )
2021	2021	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	001	6	11/23/2020	COMPETING CONTINUATION	$656,436
2021	2019	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	5	11/12/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $656,436

Issue Date FY: 2019 ( Subtotal = $537,593 )
2019	2019	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	5	4/4/2019	NON-COMPETING CONTINUATION	$537,593
														Subtotal = $537,593

Issue Date FY: 2018 ( Subtotal = $551,354 )
2018	2018	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	4	4/26/2018	NON-COMPETING CONTINUATION	$551,354
														Subtotal = $551,354

Issue Date FY: 2017 ( Subtotal = $579,659 )
2017	2017	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Child Health and Human Development Extramural Research	000	3	6/7/2017	NON-COMPETING CONTINUATION	$579,659
														Subtotal = $579,659

Issue Date FY: 2016 ( Subtotal = $599,096 )
2016	2016	ARIZONA STATE UNIVERSITY	P.O. BOX 873503	TEMPE	AZ	85287	MARICOPA	USA	Child Health and Human Development Extramural Research	000	2	4/11/2016	NON-COMPETING CONTINUATION	$599,096
														Subtotal = $599,096

Issue Date FY: 2015 ( Subtotal = $619,462 )
2015	2015	ARIZONA STATE UNIVERSITY	P.O. BOX 873503	TEMPE	AZ	85287	MARICOPA	USA	Child Health and Human Development Extramural Research	000	1	5/15/2015	NEW	$619,462
														Subtotal = $619,462

Grand Total All Awards = $5,981,856

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Social and Genetic Contributions to Children's Sleep, Health and Functioning

Award Number: R01HD079520

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2015

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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