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Imaging Neonatal Hypoxic Ischemic Injury

Award Number: R01HD074593
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/20/2024
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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Imaging Neonatal Hypoxic Ischemic Injury - Abstract Hypoxic ischemic (HI) insult damages both white matter and grey matter in infants and causes significant mortality and morbidity. To investigate the pathological mechanisms of neonatal HI injury and find satisfactory treatments, animal models of neonatal HI injury have been established and widely used. In this project, novel in vivo magnetic resonance imaging techniques that target tissue microstructure and water exchange between intra- and extra-cellular spaces will be developed to examine the progression of HI injury and the effects of therapeutic hypothermia in a neonatal mouse model. In aim 1, we will develop diffusion MRI (dMRI) based techniques to measure microstructural changes and water exchange and validated the techniques using histology. We will use these techniques to characterize the extent and severity of cell death and to predict tissue survival in edema regions. In aim 2, we will further validate the dMRI techniques developed in aim 1 using maps of metabolites and lipids generated using mass spectrometry imaging. In aim 3, the techniques developed in the first two aims will be applied to characterize HI injury in mice treated with hypothermia to study its effects and elucidate its neuroprotective mechanisms. We expect the project to extend our knowledge on the relationships between HI pathology and diagnostic markers in this mouse model and shed light on the mechanisms of HI injury and therapeutic hypothermia. This information and techniques developed in this project will be useful to design effective strategies for intervention and to monitor treatment response in studies using this or similar models.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	001	12	3/20/2025	COMPETING CONTINUATION	$97,362
2025	2022	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	000	11	3/20/2025	NON-COMPETING CONTINUATION	-$97,362
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $681,392 )
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	001	12	6/20/2024	COMPETING CONTINUATION	$681,392
2024	2022	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	000	11	6/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $681,392

Issue Date FY: 2022 ( Subtotal = $598,324 )
2022	2022	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	000	11	7/13/2022	NON-COMPETING CONTINUATION	$598,324
														Subtotal = $598,324

Issue Date FY: 2021 ( Subtotal = $598,324 )
2021	2021	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	000	10	7/7/2021	NON-COMPETING CONTINUATION	$598,324
														Subtotal = $598,324

Issue Date FY: 2020 ( Subtotal = $628,373 )
2020	2020	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	000	9	8/27/2020	NON-COMPETING CONTINUATION	$628,373
														Subtotal = $628,373

Issue Date FY: 2019 ( Subtotal = $631,691 )
2019	2019	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	000	8	7/23/2019	NON-COMPETING CONTINUATION	$631,691
														Subtotal = $631,691

Issue Date FY: 2018 ( Subtotal = $657,867 )
2018	2018	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	001	7	8/20/2018	COMPETING CONTINUATION	$658,377
2018	2017	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	000	6	7/27/2018	NON-COMPETING CONTINUATION	-$510
														Subtotal = $657,867

Issue Date FY: 2017 ( Subtotal = $300,801 )
2017	2017	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	000	6	8/14/2017	NON-COMPETING CONTINUATION	$300,801
														Subtotal = $300,801

Issue Date FY: 2016 ( Subtotal = $253,071 )
2016	2016	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	002	5	7/18/2016	NON-COMPETING CONTINUATION	$312,688
2016	2015	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Child Health and Human Development Extramural Research	000	3	6/6/2016	NON-COMPETING CONTINUATION	-$384,363
2016	2015	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	001	4	6/6/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$324,746
														Subtotal = $253,071

Issue Date FY: 2015 ( Subtotal = $384,363 )
2015	2015	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Child Health and Human Development Extramural Research	000	3	4/10/2015	NON-COMPETING CONTINUATION	$384,363
														Subtotal = $384,363

Issue Date FY: 2014 ( Subtotal = $383,179 )
2014	2014	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Child Health and Human Development Extramural Research	000	2	4/25/2014	NON-COMPETING CONTINUATION	$383,179
														Subtotal = $383,179

Issue Date FY: 2013 ( Subtotal = $394,217 )
2013	2013	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Child Health and Human Development Extramural Research	000	1	7/16/2013	NEW	$394,217
														Subtotal = $394,217

Grand Total All Awards = $5,511,602

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Imaging Neonatal Hypoxic Ischemic Injury

Award Number: R01HD074593

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/20/2024

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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