Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Children with Hypoglycemia and their Later Development (the CHYLD Study)

Award Number: R01HD069622
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2011
PERIOD OF PERFORMANCE END DATE: 07/31/2017

Group Awards By:

View Award Description

Children with Hypoglycemia and their Later Development (the CHYLD Study) - DESCRIPTION (provided by applicant): Hypoglycemia is the most common metabolic disorder of the newborn, and the only known common preventable cause of brain damage in newborn babies. However, the best approach to diagnosis and management remains unclear. One major challenge is that the blood glucose concentration at which brain damage is incurred may differ in different babies, and it is not known how low, how often, or for how long low blood glucose concentrations must occur before brain damage occurs. There have been calls, including from the NICHD1, for large follow-up studies of children in whom glucose concentrations were measured in the newborn period and encompassed a range wide enough to determine relationships between glucose concentrations and later outcome. This proposal is to conduct just such a study. Our hypothesis is that developmental performance in early childhood is related to the severity, duration and frequency of low glucose concentrations in the first week after birth. The specific aims are to determine: 1. Whether the severity, duration and frequency of low glucose concentrations recorded in the first week after birth are related to clinical and developmental outcomes at 2 and 4.5 years of age. 2. Whether these relationships differ in babies with different risk factors or perinatal histories. 3. What glucose concentrations provide the best discriminatory definition for "low" in relation to these outcomes in different groups of babies, and thus may provide an evidence-based threshold for intervention. A cohort of <500 term and late preterm babies (e35 weeks) is being recruited. All are at risk of neonatal hypoglycemia, and are managed according to current clinical guidelines. All babies also have continuous interstitial glucose monitoring for at least 48 h and up to 7 d after birth. Data from these monitors are not used for clinical management, but do provide valuable information about the severity, duration and frequency of low glucose concentrations. Approximately 40% of the babies develop hypoglycemia, clinically defined as a blood glucose concentration <2.6mM, and are therefore treated. However, a further 20-30% experience episodes of interstitial glucose concentrations <2.6mM that are not detected clinically and therefore are not treated. Children of consenting parents will be assessed at 2 and 4.5 years of age. The assessments will include standardised measures of growth, neurological function, vision, cognitive and language development, memory, executive function, general health and family environment. Data analysis will include multivariate modelling to assess the relationships between neonatal glucose concentrations and developmental outcomes, with appropriate adjustment for perinatal events and potential postnatal family and environmental influences. Results will provide a much-needed evidence base to inform clinical practice in the short term, while also providing the critical evidence base upon which randomized trials of appropriate interventions can be designed.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = -$13,852 )
2018	2015	THE UNIVERSITY OF AUCKLAND	24 PRINCES STREET	AUCKLAND		1010		NZL	Child Health and Human Development Extramural Research	000	5	12/14/2017	NON-COMPETING CONTINUATION	-$13,852
														Subtotal = -$13,852

Issue Date FY: 2015 ( Subtotal = $238,447 )
2015	2015	UNIVERSITY OF AUCKLAND	POST OFFICE BOX 2175	AUCKLAND				NZL	Child Health and Human Development Extramural Research	000	5	8/6/2015	NON-COMPETING CONTINUATION	$238,447
														Subtotal = $238,447

Issue Date FY: 2014 ( Subtotal = $395,601 )
2014	2014	UNIVERSITY OF AUCKLAND	POST OFFICE BOX 2175	AUCKLAND				NZL	Child Health and Human Development Extramural Research	000	4	7/25/2014	NON-COMPETING CONTINUATION	$395,601
														Subtotal = $395,601

Issue Date FY: 2013 ( Subtotal = $382,872 )
2013	2013	UNIVERSITY OF AUCKLAND	POST OFFICE BOX 2175	AUCKLAND				NZL	Child Health and Human Development Extramural Research	001	3	7/22/2013	EXTENSION WITH OR WITHOUT FUNDS	$382,872
2013	2012	UNIVERSITY OF AUCKLAND	POST OFFICE BOX 2175	AUCKLAND		00000		NZL	Child Health and Human Development Extramural Research	000	2	7/12/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $382,872

Issue Date FY: 2012 ( Subtotal = $352,461 )
2012	2012	UNIVERSITY OF AUCKLAND	POST OFFICE BOX 2175	AUCKLAND				NZL	Child Health and Human Development Extramural Research	000	2	8/10/2012	NON-COMPETING CONTINUATION	$352,461
														Subtotal = $352,461

Issue Date FY: 2011 ( Subtotal = $359,075 )
2011	2011	UNIVERSITY OF AUCKLAND	POST OFFICE BOX 2175	AUCKLAND				NZL	Child Health and Human Development Extramural Research	000	1	8/3/2011	NEW	$360,085
2011	2011	UNIVERSITY OF AUCKLAND	POST OFFICE BOX 2175	AUCKLAND				NZL	Child Health and Human Development Extramural Research	001	1	8/11/2011	NEW	-$1,010
														Subtotal = $359,075

Grand Total All Awards = $1,714,604

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Children with Hypoglycemia and their Later Development (the CHYLD Study)

Award Number: R01HD069622

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2011

PERIOD OF PERFORMANCE END DATE: 07/31/2017

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer