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THE EARLY GROWTH AND DEVELOPMENT STUDY: FAMILY PROCESS, GENES AND SCHOOL ENTRY

Award Number: R01HD042608
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2007
PERIOD OF PERFORMANCE END DATE: 07/31/2014

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THE EARLY GROWTH AND DEVELOPMENT STUDY: FAMILY PROCESS, GENES AND SCHOOL ENTRY - DESCRIPTION (provided by applicant): The proposed study is the continuation of the Early Growth and Development Study (EGDS), a prospective adoption design consisting 350 adoption triads (birth parents, adopted child, and adoptive parents). The overarching aim of this work is to study mechanisms of Genotype x Environment (GxE) interaction to identify environmental processes that prevent the expression of genetic risk and promote the expression of genetic resilience. We focus on mechanisms of GxE interaction along three developmental pathways: internalizing behavior, externalizing behavior, and social competence. We also explore hypotheses regarding the role of three early responding systems that are closely linked to these pathways: emergent literacy, HPA axis functioning, and executive functioning. The proposed data collection consists of multimethod, multiagent measures of genetic risk and protective factors, environmental processes, and children's behavioral and neuroregulatory development during the transition to primary school. Success or failure during this transition has long-term implications for children's mental health and drug use. Birth parent in-person assessments are proposed at child age 5, and adoptive family in-person assessments are proposed at ages 41/z, 6 (kindergarten), and 7 (first grade). The following aims are proposed: (1) To identify specific parenting processes that mediate the expression of genetic influences on children's internalizing behavior, externalizing behavior, and social competence (genotype-environment correlation); (2) to identify specific parenting processes and contextual factors that moderate genetic influences on internalizing behavior, externalizing behavior, and social competence (GxE interaction); (3) to identify mechanisms by which parenting and adoptive family contextual factors moderate genotype expression; and (4) to explore early responding systems that may moderate a child's effect on or sensitivity to the family environment. Public Health Relevance: Young children's externalizing and internalizing problems pose critical challenges for families and schools. Children who enter primary school with problems are more likely to struggle academically and to access mental health and social services as adolescents and adults. The proposed work would build an empirical foundation to help guide prevention programs administered in family settings.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2011	OREGON SOCIAL LEARNING CENTER	160 EAST 4TH AVENUE	EUGENE	OR	97401	LANE	USA	Child Health and Human Development Extramural Research	000	10	7/29/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $1,623,655 )
2011	2011	OREGON SOCIAL LEARNING CENTER	10 Shelton McMurphey Blvd	Eugene	OR	97401	LANE	USA	Child Health and Human Development Extramural Research	000	10	7/26/2011	NON-COMPETING CONTINUATION	$1,623,655
														Subtotal = $1,623,655

Issue Date FY: 2010 ( Subtotal = $1,598,558 )
2010	2010	OREGON SOCIAL LEARNING CENTER	10 Shelton McMurphey Blvd	Eugene	OR	97401	LANE	USA	Child Health and Human Development Extramural Research	000	9	7/29/2010	NON-COMPETING CONTINUATION	$1,598,558
														Subtotal = $1,598,558

Issue Date FY: 2009 ( Subtotal = $1,657,977 )
2009	2009	OREGON SOCIAL LEARNING CENTER	10 Shelton McMurphey Blvd	Eugene	OR	97401	LANE	USA	Child Health and Human Development Extramural Research	000	8	7/1/2009	NON-COMPETING CONTINUATION	$1,657,977
														Subtotal = $1,657,977

Issue Date FY: 2008 ( Subtotal = $1,506,384 )
2008	2008	OREGON SOCIAL LEARNING CENTER	160 EAST 4TH AVENUE	EUGENE	OR	97401	LANE	USA	Child Health and Human Development Extramural Research	000	7	8/15/2008	NON-COMPETING CONTINUATION	$1,506,384
														Subtotal = $1,506,384

Issue Date FY: 2007 ( Subtotal = $1,298,605 )
2007	2007	OREGON SOCIAL LEARNING CENTER	160 EAST 4TH AVENUE	EUGENE	OR	97401	LANE	USA	Child Health and Human Development Extramural Research	000	6	9/10/2007	COMPETING CONTINUATION	$1,298,605
														Subtotal = $1,298,605

Issue Date FY: 2006 ( Subtotal = $1,031,733 )
2006	2006	GEORGE WASHINGTON UNIVERSITY	2100 M STREET, NW, SUITE 310	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	5	9/20/2006	NON-COMPETING CONTINUATION	$1,031,733
														Subtotal = $1,031,733

Issue Date FY: 2005 ( Subtotal = $1,752,584 )
2005	2005	GEORGE WASHINGTON UNIVERSITY	2100 M STREET, NW, SUITE 310	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	4	8/24/2005	NON-COMPETING CONTINUATION	$1,752,584
														Subtotal = $1,752,584

Issue Date FY: 2004 ( Subtotal = $1,623,314 )
2004	2004	GEORGE WASHINGTON UNIVERSITY	2100 M STREET, NW, SUITE 310	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Indicates awards funded from multiple programs	000	3	9/10/2004	NON-COMPETING CONTINUATION	$1,623,314
														Subtotal = $1,623,314

Issue Date FY: 2003 ( Subtotal = $1,434,074 )
2003	2003	GEORGE WASHINGTON UNIVERSITY	2100 M STREET, NW, SUITE 310	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Indicates awards funded from multiple programs	000	2	7/16/2003	NON-COMPETING CONTINUATION	$1,434,074
														Subtotal = $1,434,074

Issue Date FY: 2002 ( Subtotal = $1,085,440 )
2002	2002	GEORGE WASHINGTON UNIVERSITY	2100 M STREET, NW, SUITE 310	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Indicates awards funded from multiple programs	000	1	9/20/2002	NEW	$1,085,440
														Subtotal = $1,085,440

Grand Total All Awards = $14,612,324

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THE EARLY GROWTH AND DEVELOPMENT STUDY: FAMILY PROCESS, GENES AND SCHOOL ENTRY

Award Number: R01HD042608

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2007

PERIOD OF PERFORMANCE END DATE: 07/31/2014

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