Sunday, September 24, 2023 9/24/2023

Pre- and Peri-natal Predictors of Childhood Obesity

Award Number: R01HD034568
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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DESCRIPTION (provided by applicant): As children enter early adolescence, cardiovascular and metabolic consequences of obesity become more apparent. Studies in older children show that obesity and central fat distribution are associated with these outcomes. But how did the children get there in the first place? This is a key question for chronic disease prevention. A now-vast animal experimental literature and a growing human counterpart demonstrate that factors operating at the earliest stages of human development-even before birth-can have lifelong consequences for obesity and cardiometabolic outcomes. Yet major questions still exist regarding how pre- and peri-natal factors operate, through gain in weight and adiposity, to influence these outcomes. In analyses from the previous cycle of "Pre- and peri-natal predictors of childhood obesity, the findings imply both that the endocrine milieu at the time of birth is different from later in life, and that it is likely to be a key driver of weight gain in the first months of life, itself a strong predictor of later obesity and cormorbidities. While these observations are consistent with endocrine knowledge emerging from animal experiments, they raise several questions: 7 To what extent are prenatal factors such as maternal nutrition (e.g., fatty acids, vitamin D), smoking, gestational weight gain, and gestational diabetes associated with perinatal hormone levels? 7 What other hormones are involved in these pathways? In particular, what are the roles of insulin and insulin-like growth factors (IGFs), which are correlated with leptin levels? 7 If these hormones influence childhood weight gain, do they also influence gain in adiposity, fat distribution, components of the metabolic syndrome and vascular dysfunction in early adolescence? 7 To what extent are these influences mediated by adiposity-related inflammation? The overall goal of this renewal of R01 HD 034568-10 is to examine associations of potentially modifiable prenatal factors, hormone levels in umbilical cord blood, gains in weight and adiposity in childhood, adiposity- related inflammation, and cardiometabolic outcomes in early adolescence. including components of the metabolic syndrome, carotid intima-media thickness, and endothelial dysfunction. Extending the productive pre-birth cohort study Project Viva through the age of 11 years provides the opportunity to meet this challenge. The results of this research will lead to new scientific knowledge about the drivers of growth and adiposity in childhood and may very well lead to new avenues for prevention of obesity, diabetes, and cardiovascular disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $1,353,987 )
2023	2023	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Child Health and Human Development Extramural Research	002	21	8/17/2023	NON-COMPETING CONTINUATION	$1,353,987
2023	2022	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Child Health and Human Development Extramural Research	001	20	7/24/2023	COMPETING CONTINUATION	$762,146
2023	2021	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Child Health and Human Development Extramural Research	000	19	7/24/2023	NON-COMPETING CONTINUATION	-$762,146


Issue Date FY: 2022 ( Subtotal = $1,371,511 )
2022	2022	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	001	20	7/22/2022	COMPETING CONTINUATION	$1,371,511
2022	2021	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	19	7/14/2022	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2021 ( Subtotal = $1,684,677 )
2021	2021	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	001	19	2/9/2021	NON-COMPETING CONTINUATION	$137,525
2021	2021	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	19	1/15/2021	NON-COMPETING CONTINUATION	$1,547,152


Issue Date FY: 2020 ( Subtotal = $1,833,058 )
2020	2020	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	002	18	2/6/2020	NON-COMPETING CONTINUATION	$1,833,058
2020	2019	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	17	11/11/2019	SUPPLEMENT FOR EXPANSION	$0
2020	2019	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	001	17	11/11/2019	SUPPLEMENT FOR EXPANSION	$0


Issue Date FY: 2019 ( Subtotal = $1,924,169 )
2019	2019	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	002	17	5/23/2019	SUPPLEMENT FOR EXPANSION	$157,414
2019	2019	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	001	17	5/17/2019	SUPPLEMENT FOR EXPANSION	$130,312
2019	2019	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	17	1/4/2019	NON-COMPETING CONTINUATION	$1,636,443


Issue Date FY: 2018 ( Subtotal = $1,659,799 )
2018	2018	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	16	1/19/2018	NON-COMPETING CONTINUATION	$1,493,818
2018	2018	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	001	16	4/26/2018	NON-COMPETING CONTINUATION	$165,981


Issue Date FY: 2017 ( Subtotal = $1,024,170 )
2017	2017	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	15	2/6/2017	EXTENSION WITH OR WITHOUT FUNDS	$1,024,170
2017	2017	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	002	15	6/6/2017	EXTENSION WITH OR WITHOUT FUNDS	$158,182
2017	2016	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	001	14	6/6/2017	EXTENSION WITH OR WITHOUT FUNDS	-$158,182


Issue Date FY: 2016 ( Subtotal = $914,581 )
2016	2016	HARVARD PILGRIM HEALTH CARE, INC	93 WORCESTER STREET	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	14	1/28/2016	EXTENSION WITH OR WITHOUT FUNDS	$914,581


Issue Date FY: 2012 ( Subtotal = $1,129,268 )
2012	2012	HARVARD PILGRIM HEALTH CARE, INC	93 WORCESTER STREET	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	10	3/21/2012	COMPETING CONTINUATION	$1,129,268


Issue Date FY: 2011 ( Subtotal = $0 )
2011	2009	HARVARD PILGRIM HEALTH CARE, INC	93 WORCESTER STREET	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	9	7/14/2011	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2009 ( Subtotal = $759,273 )
2009	2009	HARVARD PILGRIM HEALTH CARE, INC	93 WORCESTER STREET	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	9	6/16/2009	NON-COMPETING CONTINUATION	$669,273
2009	2009	HARVARD PILGRIM HEALTH CARE, INC	93 WORCESTER STREET	WELLESLEY	MA	02481	NORFOLK	USA	Trans-NIH Recovery Act Research Support	001	9	9/29/2009	SUPPLEMENT FOR EXPANSION	$90,000


Issue Date FY: 2008 ( Subtotal = $977,847 )
2008	2008	HARVARD PILGRIM HEALTH CARE, INC	93 WORCESTER STREET	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	8	6/27/2008	NON-COMPETING CONTINUATION	$977,847


Issue Date FY: 2007 ( Subtotal = $1,031,835 )
2007	2007	HARVARD PILGRIM HEALTH CARE, INC	93 WORCESTER STREET	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	7	7/26/2007	NON-COMPETING CONTINUATION	$1,031,835


Issue Date FY: 2006 ( Subtotal = $1,069,968 )
2006	2006	HARVARD PILGRIM HEALTH CARE, INC	93 WORCESTER STREET	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	6	7/28/2006	COMPETING CONTINUATION	$1,069,968


Issue Date FY: 2002 ( Subtotal = $629,181 )
2002	2002	HARVARD PILGRIM HEALTH CARE, INC							Child Health and Human Development Extramural Research	000	5	7/12/2002	NON-COMPETING CONTINUATION	$629,181


Issue Date FY: 2001 ( Subtotal = $722,096 )
2001	2001	HARVARD PILGRIM HEALTH CARE, INC	20 OVERLAND STREET	BOSTON	MA	02215	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	4	9/10/2001	NON-COMPETING CONTINUATION	$722,096


Issue Date FY: 2000 ( Subtotal = $891,151 )
2000	2000	HARVARD PILGRIM HEALTH CARE, INC	93 WORCESTER STREET	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	3	8/24/2000	NON-COMPETING CONTINUATION	$891,151


Issue Date FY: 1999 ( Subtotal = $876,462 )
1999	1999	HARVARD PILGRIM HEALTH CARE, INC	93 WORCESTER STREET	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	2	7/12/1999	NON-COMPETING CONTINUATION	$876,462


Issue Date FY: 1998 ( Subtotal = $487,650 )
1998	1998	HARVARD PILGRIM HEALTH CARE, INC	93 WORCESTER STREET	WELLESLEY	MA	02481	NORFOLK	USA	Child Health and Human Development Extramural Research	000	1	6/25/1998	NEW	$487,650


Grand Total All Awards = $20,340,683

Sum of Action Amount is $20,340,683;

Grand Total = $20,340,683

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Pre- and Peri-natal Predictors of Childhood Obesity

Award Number: R01HD034568

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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