Friday, April 26, 2024 4/26/2024

Trophoblast Differentiation

Award Number: R01HD020676
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

PROJECT SUMMARY/ABSTRACT Hemochorial placentation occurs in many mammalian species including primates and rodents. It ensures the most intimate contact between maternal and embryonic compartments and requires specialized adjustments. Among these adjustments is the need for extensive remodeling of the maternal uterine spiral arteries. Uterine vascular modifications are required for the delivery of nutrients to the fetus. Disruptions in this fundamental process lead to diseases of pregnancy and placentation, and result in impaired nutrient transport to the fetus, including the delivery of oxygen. Hypoxemia leads to a range of disruptive events within the fetus that have potentially long-lasting postnatal impacts on health and disease. Mechanisms controlling uterine spiral artery remodeling remain poorly understood. Central to the vascular remodeling process is a specialized population of trophoblast cells referred to as invasive trophoblast or alternatively as extravillous trophoblast. Regulatory processes controlling differentiation and function of the extravillous trophoblast cell lineage is the focus of this proposal. The rat is used as an experimental model in this investigation because it exhibits deep intrauterine trophoblast invasion and extensive uterine spiral artery remodeling. These events are remarkably similar to that observed in human placentation. The experimental effort is based on our prior establishment and extensive characterization of in vitro and in vivo models for studying rat hemochorial placentation. Through these efforts we discovered key regulators that promote development of the invasive trophoblast lineage: i) Fos like antigen 1/JunB protooncogene; ii) hypoxia/hypoxia inducible factor/lysine demethylase 3A/matrix metalloproteinase 12. These regulators contribute to establishing tissue plasticity and safeguard placental health. Most importantly, we have determined that plasticity is a hallmark of a healthy placenta. In this proposal we utilize FOS Like Antigen 1/JunB protooncogene and hypoxia/hypoxia inducible factor/ lysine demethylase 3A/matrix metalloproteinase 12 regulatory circuits as centerpieces and guides to mechanisms controlling the development of the extravillous trophoblast lineage. The proposed research provides an innovative approach to studying hemochorial placentation. Collectively, the research is directed toward elucidating molecular mechanisms underlying physiological processes that ensure appropriate hemochorial placentation. This approach will lead to the identification of conserved regulatory pathways controlling the extravillous trophoblast lineage, which will create opportunities for new scientific and applied pursuits.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $512,163 )
2024	2024	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	3901 RAINBOW BLVD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	35	12/26/2023	NON-COMPETING CONTINUATION	$512,163
														Subtotal = $512,163

Issue Date FY: 2023 ( Subtotal = $571,854 )
2023	2023	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	3901 RAINBOW BLVD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	001	34	3/3/2023	COMPETING CONTINUATION	$571,854
2023	2021	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	3901 RAINBOW BLVD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	33	2/23/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $571,854

Issue Date FY: 2021 ( Subtotal = $462,534 )
2021	2021	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	4330 SHAWNEE MISSION PKWY	SHAWNEE MISSION	KS	66205	JOHNSON	USA	Child Health and Human Development Extramural Research	000	33	4/12/2021	NON-COMPETING CONTINUATION	$462,534
														Subtotal = $462,534

Issue Date FY: 2020 ( Subtotal = $471,973 )
2020	2020	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	4330 SHAWNEE MISSION PKWY	SHAWNEE MISSION	KS	66205	JOHNSON	USA	Child Health and Human Development Extramural Research	000	32	4/30/2020	NON-COMPETING CONTINUATION	$471,973
														Subtotal = $471,973

Issue Date FY: 2019 ( Subtotal = $471,973 )
2019	2019	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	4330 SHAWNEE MISSION PKWY	SHAWNEE MISSION	KS	66205	JOHNSON	USA	Child Health and Human Development Extramural Research	000	31	4/25/2019	NON-COMPETING CONTINUATION	$471,973
														Subtotal = $471,973

Issue Date FY: 2018 ( Subtotal = $471,973 )
2018	2018	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	4330 SHAWNEE MISSION PKWY	SHAWNEE MISSION	KS	66205	JOHNSON	USA	Child Health and Human Development Extramural Research	000	30	5/23/2018	NON-COMPETING CONTINUATION	$471,973
														Subtotal = $471,973

Issue Date FY: 2017 ( Subtotal = $471,973 )
2017	2017	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	4330 SHAWNEE MISSION PKWY	SHAWNEE MISSION	KS	66205	JOHNSON	USA	Child Health and Human Development Extramural Research	002	29	9/26/2017	COMPETING CONTINUATION	$52,496
2017	2017	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	4330 SHAWNEE MISSION PKWY	SHAWNEE MISSION	KS	66205	JOHNSON	USA	Child Health and Human Development Extramural Research	000	29	4/24/2017	COMPETING CONTINUATION	$471,973
2017	2016	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	4330 SHAWNEE MISSION PKWY	SHAWNEE MISSION	KS	66205	JOHNSON	USA	Child Health and Human Development Extramural Research	001	28	9/26/2017	EXTENSION WITH OR WITHOUT FUNDS	-$52,496
														Subtotal = $471,973

Issue Date FY: 2016 ( Subtotal = $394,163 )
2016	2016	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	28	4/22/2016	EXTENSION WITH OR WITHOUT FUNDS	$394,163
														Subtotal = $394,163

Issue Date FY: 2015 ( Subtotal = $385,221 )
2015	2015	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	27	4/7/2015	NON-COMPETING CONTINUATION	$385,221
														Subtotal = $385,221

Issue Date FY: 2014 ( Subtotal = $381,168 )
2014	2014	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	26	4/29/2014	NON-COMPETING CONTINUATION	$381,168
														Subtotal = $381,168

Issue Date FY: 2013 ( Subtotal = $369,422 )
2013	2013	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	001	25	5/20/2013	NON-COMPETING CONTINUATION	$19,073
2013	2013	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	25	5/1/2013	NON-COMPETING CONTINUATION	$350,349
														Subtotal = $369,422

Issue Date FY: 2012 ( Subtotal = $386,492 )
2012	2012	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	001	24	7/13/2012	COMPETING CONTINUATION	$383,933
2012	2012	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	002	24	7/17/2012	COMPETING CONTINUATION	$2,559
2012	2011	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	23	7/6/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $386,492

Issue Date FY: 2011 ( Subtotal = $284,098 )
2011	2011	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	23	6/3/2011	NON-COMPETING CONTINUATION	$284,098
														Subtotal = $284,098

Issue Date FY: 2010 ( Subtotal = $295,936 )
2010	2010	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	22	4/27/2010	NON-COMPETING CONTINUATION	$295,936
														Subtotal = $295,936

Issue Date FY: 2009 ( Subtotal = $298,925 )
2009	2009	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	21	5/7/2009	NON-COMPETING CONTINUATION	$298,925
														Subtotal = $298,925

Issue Date FY: 2008 ( Subtotal = $318,613 )
2008	2008	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	20	4/16/2008	NON-COMPETING CONTINUATION	$298,925
2008	2008	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	001	20	8/21/2008	SUPPLEMENT FOR EXPANSION	$19,688
														Subtotal = $318,613

Issue Date FY: 2007 ( Subtotal = $305,025 )
2007	2007	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	19	5/7/2007	COMPETING CONTINUATION	$305,025
														Subtotal = $305,025

Issue Date FY: 2006 ( Subtotal = $363,991 )
2006	2006	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	18	5/25/2006	NON-COMPETING CONTINUATION	$363,991
														Subtotal = $363,991

Issue Date FY: 2005 ( Subtotal = $372,750 )
2005	2005	UNIVERSITY OF KANSAS, MEDICAL CENTER	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	16	3/30/2005	NON-COMPETING CONTINUATION	$372,750
														Subtotal = $372,750

Issue Date FY: 2004 ( Subtotal = $483,000 )
2004	2004	UNIVERSITY OF KANSAS, MEDICAL CENTER	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	001	15	5/14/2004	SUPPLEMENT FOR EXPANSION	$110,250
2004	2004	UNIVERSITY OF KANSAS, MEDICAL CENTER	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	15	4/8/2004	NON-COMPETING CONTINUATION	$372,750
														Subtotal = $483,000

Issue Date FY: 2003 ( Subtotal = $483,000 ) (Continued on the next page)
2003	2003	UNIVERSITY OF KANSAS, MEDICAL CENTER	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	001	14	9/11/2003	SUPPLEMENT FOR EXPANSION	$110,250
Grand Total All Awards = $9,382,290

Page 1 of 2 (58 items)12

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Trophoblast Differentiation

Award Number: R01HD020676

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer