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Pax2 functions in postnatal retinal and optic nerve astrocytes

Award Number: R01EY038806
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2030

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Pax2 functions in postnatal retinal and optic nerve astrocytes - Project Summary This proposal investigates the underlying causes of human ocular disorders using complex in vivo conditional (cre-lox) mouse genetics, histology, immunohistochemistry, confocal microscopy, electron microscopy, small animal ocular imaging (OCT, SLO), along with flow cytometry coupled with single-cell NEXTgen sequencing and bioinformatics. We aim to understand basic, mechanistic questions about the multiple functions of Pax2-expressing astrocytes in the postnatal eye, including during retinal vasculature outgrowth and homeostasis. We will also investigate the requirements for Pax2+ astrocytes relative to optic nerve RGC axon health, and the myelination of these axons by oligodendrocytes. In both aims we will take advantage of a Dct-Cre transgenic driver that induces postnatal Pax2 conditional phenotypes, without embryonic ocular coloboma malformations. Proposed experiments will study retinal and optic nerve astrocytes during postnatal development and adulthood. Incorporation of a Pax2- GFP knock-in mouse allele in our experiments will facilitate the isolation of control and Dct- Cre;Pax2 mutant lineage cells for molecular profiling. These outcomes will contribute new information relevant for underlying pathology of a range of congenital cavitary optic disc anomalies (CODA). Our findings should also be directly informative for morning glory disc anomaly syndrome (MGDA), glaucoma, and optic neuritis. On a broader level, we will also contribute to a deeper understanding of CNS myelination and demyelinating diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $437,262 )
2026	2026	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Vision Research	000	1	6/24/2026	NEW	$437,262
														Subtotal = $437,262

Grand Total All Awards = $437,262

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Pax2 functions in postnatal retinal and optic nerve astrocytes

Award Number: R01EY038806

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2030

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