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Recurrent interactions in layer 2/3 ferret visual cortex

Award Number: R01EY037270
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2030

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Recurrent interactions in layer 2/3 ferret visual cortex - PROJECT SUMMARY/ABSTRACT Measuring the functional connectivity between cortical neurons in the primary visual cortex (V1) remains a pivotal challenge in neuroscience, particularly in understanding how selective visual responses emerge from myriad synaptic inputs. This proposal aims to identify the principles of functional connectivity within layer 2/3 of ferret V1, building upon previous work in mouse and classical work in carnivores and primates. Our central hypothesis posits that inter-columnar connections, following the functional similarity principles observed in mouse V1, are essential for feature selectivity. We propose two main aims. First, using all-optical interrogation, we will perturb and map excitatory and inhibitory neuronal interactions within and between orientation columns, testing hypotheses about the spatial profile of excitatory connectivity, the functional specificity of inhibitory interneurons, and the dynamic recruitment of functional connections. Second, we will employ two-photon calcium imaging to map and analyze the organization and integration of synaptic inputs on the dendritic tree during diverse visual stimuli presentations. These studies will assess the functional similarity of long-range excitatory inputs and their preferential location on distal dendritic tufts, as well as the dynamic recruitment of inputs in shaping somatic responses. Through these approaches, our research aims to uncover novel computational circuit motifs in ferret V1, advancing our understanding of cortical circuits and informing the development of brain-inspired artificial intelligence.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $615,414 )
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Vision Research	000	1	4/2/2026	NEW	$615,414
														Subtotal = $615,414

Grand Total All Awards = $615,414

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Recurrent interactions in layer 2/3 ferret visual cortex

Award Number: R01EY037270

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2030

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