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Identifying the signals leading to the onset and progression of FECD phenotypes using a mouse model

Award Number: R01EY037246
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2026
PERIOD OF PERFORMANCE END DATE: 02/28/2031

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Identifying the signals leading to the onset and progression of FECD phenotypes using a mouse model - PROJECT SUMMARY Fuchs Endothelial corneal dystrophy is a blinding disease for which there is no cure. This condition affects 4- 7% of individuals over 40, and results in an economic burden of $300 million. Corneal transplantation is the prevalent treatment which has several disadvantages such as graft rejection, and secondary ocular complications. A major hindrance to the development of therapies for FECD is the lack of understanding of the molecular mechanisms which lead to the onset and progression of this condition. The non-existence of an animal model that had all the FECD phenotypes was a major cause behind this. We recently developed a mouse model that contains the major features of FECD – guttae (sub-endothelial blebs), corneal endothelial cell loss, and corneal edema. Using this animal model, we plan to elucidate the signals leading to the onset and progression of FECD phenotypes using the following specific aims. Aim 1 will determine the role of Descemet’s membrane changes in corneal endothelial functions. Aim 2 will determine the role of ubiquitin- proteasome system inactivity in development of FECD phenotypes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $641,479 )
2026	2026	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Vision Research	000	1	5/1/2026	NEW	$641,479
														Subtotal = $641,479

Grand Total All Awards = $641,479

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Identifying the signals leading to the onset and progression of FECD phenotypes using a mouse model

Award Number: R01EY037246

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2026

PERIOD OF PERFORMANCE END DATE: 02/28/2031

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