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The role of lens remodeling in childhood myopia

Award Number: R01EY037071
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2030

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The role of lens remodeling in childhood myopia - PROJECT SUMMARY The long-term goal of the proposed research is to advance our knowledge of the optics of childhood myopia, with a focus on the role of the lens. In the period of childhood when myopia develops, the evolution of the refractive state of the eye is determined primarily by the combined effects of lens remodeling and ocular elongation. However, our understanding of this mechanism remains very limited. To address this gap, the project will produce new technologies to measure the full three-dimensional lens shape, ocular biometry, central and peripheral refraction, and their changes with accommodation in children. These new technologies will be used to discover how lens remodeling and ocular elongation combine to regulate ocular defocus in children in the age range of myopia onset. This new knowledge will help develop more targeted optical strategies to control myopia progression. There are three aims: Aim 1: To characterize the lens compensatory mechanism and its role in myopia development and control. A longitudinal study will be conducted to quantify full lens shape, ocular distances and refraction in children before and during the development of myopia. The data will be used to verify that a) there is a coupling of lens remodeling with ocular elongation that helps regulate ocular defocus through a compensatory effect, and b) this coupling and compensatory effect are different in emmetropic, myopic, and myopia control groups. Aim 2: To characterize changes in peripheral defocus with accommodation during the phase of lens remodeling in children. A novel instrument will be developed to enable simultaneous measurements of lens shape, ocular biometry, and defocus across a wide range of field angles and accommodative demands in children. The instrument will be used in a longitudinal study to quantify the age- and accommodation dependence of lens and ocular biometry and peripheral defocus. The data will be used to assess the role of the crystalline lens on ocular peripheral defocus, particularly during accommodation, which is highly relevant given the expected role of peripheral defocus and near work in myopia development. Aim 3: To generate a database of computational models that replicate eye growth, lens remodeling, accommodation, and their effect on central and peripheral defocus. The critical need for better models of the eye in childhood was highlighted in the recent report on myopia published by the National Academies. The goal of this aim is to develop the first database of anatomically accurate longitudinal eye models that replicate the real eyes of individual children before and during myopia development. It is envisioned that the database will be a resource that will enable designers of optical corrections for myopia control to simulate their designs on computerized replicates of real eyes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $628,100 )
2026	2026	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Vision Research	000	1	4/28/2026	NEW	$628,100
														Subtotal = $628,100

Grand Total All Awards = $628,100

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The role of lens remodeling in childhood myopia

Award Number: R01EY037071

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2030

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