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Changes in Globe Shape in Response to Myopia Treatment

Award Number: R01EY036506
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2026
PERIOD OF PERFORMANCE END DATE: 12/31/2030

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Changes in Globe Shape in Response to Myopia Treatment - Project Summary/Abstract The prevalence of myopia is predicted to reach 50% of the world population by the year 2050. Myopia has been extensively studied for decades to better understand its underlying mechanisms of development and progression, but they are still not fully understood. The importance of peripheral retina in myopia development was first demonstrated in animal models, where manipulating peripheral defocus altered foveal refractive error even in the absence of an intact fovea. This finding redirected the approach of developing more effective treatment strategies toward altering the peripheral retinal defocus profile in order to slow down the progression of myopia. The treatment strategy pertinent to this proposal uses multifocal soft contact lenses (MSCL). Optical defocus and eye shapes have been characterized in the peripheral retina of myopic eyes. However, these measurements have been limited to ±40° from the fovea due to limited field of view (FOV) of currently available autorefractors and biometers. Any far peripheral measurements have been made using low-resolution, cumbersome and highly expensive magnetic resonance imaging (MRI). Here, we propose a pan-retinal optical coherence tomography (OCT) system capable of imaging of the entire globe, extending out to the ora serrata, in living human eyes in a single measurement without the need for stitching smaller FOV images together. This technological innovation will allow the first opportunity to study ocular shape changes in response to refractive error development and myopia control treatments. Other studies showing myopic eyes are less oblate than emmetropic eyes, have either been limited in FOV or used MRI. Recently, a randomized clinical trial, the Bifocal Lenses In Nearsighted Kids (BLINK) study, demonstrated that MSCL with +2.50D addition power inhibited axial elongation more at the fovea than at the periphery (i.e., causing a more oblate shape in response to myopia treatment). Given the limitation of smaller FOV with currently available instruments, it has not been possible to study the globe shape in its entirety, leaving critical questions in myopic control unanswered such as: (i) how far into the periphery does the treatment benefit extend?, and (ii) is the globe actually smaller following myopia control with MSCL or merely shorter because of a different, less oblate shape? With the proposed pan-retinal OCT system, we can now fill this gap of global shape information including previously inaccessible locations in the peripheral retina. Myopic children (7-11 years old) will be monitored through global imaging during the course of the MSCL treatment (+2.50D addition power) to study its effect – through which we will gain further insights into designing more effective myopia treatments, as we expand our knowledge of the far peripheral retina extending out to the ora serrata.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $747,274 )
2026	2026	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Vision Research	000	1	6/23/2026	NEW	$747,274
														Subtotal = $747,274

Grand Total All Awards = $747,274

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Changes in Globe Shape in Response to Myopia Treatment

Award Number: R01EY036506

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2026

PERIOD OF PERFORMANCE END DATE: 12/31/2030

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