Thursday, January 1, 2026 1/1/2026

Regulation of Retinal Neurogenesis by Foxp1

Award Number: R01EY035158
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2023
PERIOD OF PERFORMANCE END DATE: 11/30/2028

Group Awards By:

View Award Description

Regulation of Retinal Neurogenesis by Foxp1 - PROJECT SUMMARY: Normal retinal function and vision depends upon generation of multiple classes of retinal cells during development. A central challenge is to define molecular mechanisms that enable a diversity of neurons and glia to be generated from progenitors in correct proportions during development. Prior studies have shown that progenitors undergo changes in competence to generate retinal cell types, but knowledge is incomplete regarding factors that function to regulate temporal patterning of progenitors to drive changes in competence. We thus hypothesize that Foxp1 functions as an early temporal transcription factor, and that temporally regulated Foxp1 gene expression governs the formation of retinal cell types generated during early retinal development, such as retinal ganglion cells, horizontal cells, cone photoreceptors and early-born amacrine cells. To test this in developing mouse retina, we will use genetic approaches to achieve loss or gain of Foxp1 to: 1) Define Foxp1 targets and changes in chromatin accessibility, 2) Determine whether Foxp1 can reactivate competence to generate early-born retinal cell types in late RPCs, and 3) Determine whether Dicer regulates regulates temporal expression of Foxp1. This study will provide mechanistic insight into how Foxp1 functions in progenitors to regulate the genesis of early-born retinal neurons, and may facilitate strategies to generate early retinal cell types lost to disease or injury, such as retinal ganglion cells and cones.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $568,043 )
2026	2026	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	000	3	12/4/2025	NON-COMPETING CONTINUATION	$568,043
														Subtotal = $568,043

Issue Date FY: 2025 ( Subtotal = $578,854 )
2025	2025	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	000	2	11/21/2024	NON-COMPETING CONTINUATION	$578,854
														Subtotal = $578,854

Issue Date FY: 2024 ( Subtotal = $586,269 )
2024	2024	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	000	1	11/21/2023	NEW	$586,269
														Subtotal = $586,269

Grand Total All Awards = $1,733,166

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Regulation of Retinal Neurogenesis by Foxp1

Award Number: R01EY035158

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2023

PERIOD OF PERFORMANCE END DATE: 11/30/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer