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Sensory Substitution and Brain Plasticity Following Vision Loss

Award Number: R01EY034897
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2024
PERIOD OF PERFORMANCE END DATE: 04/14/2025

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Sensory Substitution and Brain Plasticity Following Vision Loss - Visual sensory substitution devices, in which images from a video camera are converted to a cross-modal signal that is then presented to the subjects in place of direct visual information, offer an alternative, non-surgical approach for the blind to appreciate aspects of their immediate environment. These non-invasive, low-cost technologies can also offer higher visual acuity and wider fields of view than currently available retinal and cortical implants. However, sensory substitution devices are rarely adopted to interpret and translate complex, natural environments for daily use by blind individuals partly because of their impracticality. In addition, little is known about the perceptual and behavioral consequences of delivering new patterns of information as an alternative sense when the visual system is damaged at different ages. The metabolic and functional processes that allow the deprived human visual cortex for enhancing cross-modal plasticity have not been clearly defined either. These research gaps must be filled before sensory substitution can be exploited as a method of vision rehabilitation for improving function and independence while reducing the associated costs of blindness. The goal of this project is to develop and refine sensory substitution technologies and to identify the determinants of cross-modal plasticity in brains deprived of visual input in order to facilitate sensory substitution. To achieve this goal, we will incorporate artificial intelligence (AI) to simplify images of complex, natural environments into isolated objects for sensory substitution. We will then use magnetic resonance imaging (MRI) and spectroscopy (MRS), combined with behavioral assessments to examine the neural substrates of sensory substitution in early and late blind subjects. We will leverage tactile and auditory substitution stimuli to determine how changes in neurochemicals reflect the cross-modal activity of visually deprived brains. We will also test how training with AI can help blind individuals interpret visual environmental cues in a more meaningful way. Feedback from the behavioral and neurobiological results will help refine our sensory substitution devices. Aim 1: To improve sensory substitution toward practical use, we will use AI and 3D coding to convert complex everyday scenarios into simplified and aesthetically engaging versions that aid both immediate task performance and sensory substitution training. Aim 2: To determine how visual processing pathways in the brain adapt to vision loss, we will employ advanced MRI and MRS to unveil the structural, metabolic, and functional brain properties in participants with different onset ages and durations of blindness before training. Aim 3: To determine the effects of sensory substitution training on visual processing pathways and performance of the blind, we will use advanced MRI and MRS to determine if cross-modal perceptual learning alters the deprived visual cortex toward a more plastic state via modulating its excitatory-inhibitory balance and choline levels. We will also examine the neurobehavioral changes that occur when identifying and locating the objects of interest using auditory or tactile stimuli with and without AI-assisted image deconstruction.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Vision Research	000	2	4/3/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $745,798 )
2025	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Vision Research	000	2	5/13/2025	NON-COMPETING CONTINUATION	$745,798
														Subtotal = $745,798

Issue Date FY: 2024 ( Subtotal = $745,798 )
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Vision Research	000	1	12/12/2023	NEW	$745,798
														Subtotal = $745,798

Grand Total All Awards = $1,491,596

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Sensory Substitution and Brain Plasticity Following Vision Loss

Award Number: R01EY034897

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2024

PERIOD OF PERFORMANCE END DATE: 04/14/2025

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