Friday, October 31, 2025 10/31/2025

Stereopsis and Suppression in Strabismus and Amblyopia

Award Number: R01EY034370
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2026

Group Awards By:

View Award Description

Stereopsis and Suppression in Strabismus and Amblyopia - Abstract Amblyopia (‘lazy eye’) is a neuro-development disorder of the visual cortex that occurs early in life and affects about 3% of the population worldwide. Amblyopia is associated with reduced visual acuity and contrast sensitivity in the non-dominant eye. In addition, the majority of individuals with amblyopia do not have measurable stereopsis or the ability to perceive depth from binocular information, which negatively impacts many tasks of daily life including eye-hand coordination and navigation. While studies have shown that about 25% of the amblyopic population does have residual stereopsis, the retinal locus that mediates this function is unknown. This proposal tests the hypothesis that when stereopsis is present in amblyopia, it is the periphery and not the central visual field that mediates depth perception. The first aim uses a novel procedure to map stereopsis in both central and peripheral locations to determine whether residual stereopsis is in fact mediated by the periphery. Our pilot data suggest that it is the periphery that mediates stereopsis in amblyopia. We will also determine whether this peripheral stereopsis accounts for fusional vergence, the movement of the two eyes to fuse monocular images to form a binocular percept. The second aim examines the relation between residual stereopsis and the documented suppression of the non-dominant eye under conditions of binocular viewing. We will measure the suppression zone for each individual and relate it to the zone of stereo-deficiency measured for that same individual. This within-participant comparison is essential to understanding the relation between suppression and stereo-deficiency in this special group of amblyopic individuals who have residual stereopsis. This group comprises about 50% of those with anisometropia (unequal refractive error), and about 10-40% of those with strabismus (eye deviation). This study will characterize each observer’s capacity for stereopsis across the visual field including the periphery, which has been ignored previously. The third aim will use electroencephalography (EEG) combined with a procedure to localize cortical source that produces the signals to understand the neural basis of suppression in individuals with and without stereopsis, and how well the non-dominant eye signal is represented on its own, and in the presence of a stimulus in the other eye, as well as how the two eyes’ signals are combined at different levels of the cortical hierarchy. If the peripheral visual field has a significant contribution to stereopsis in amblyopia, our study will establish the importance of clinically evaluating the potential for stereopsis in the periphery and for training peripheral locations to improve stereopsis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $395,857 )
2025	2025	THE SMITH-KETTLEWELL EYE RESEARCH INSTITUTE	2318 FILLMORE ST	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Vision Research	000	4	8/4/2025	NON-COMPETING CONTINUATION	$395,857
														Subtotal = $395,857

Issue Date FY: 2024 ( Subtotal = $405,688 )
2024	2024	THE SMITH-KETTLEWELL EYE RESEARCH INSTITUTE	2318 FILLMORE ST	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Vision Research	000	3	7/1/2024	NON-COMPETING CONTINUATION	$405,688
														Subtotal = $405,688

Issue Date FY: 2023 ( Subtotal = $394,889 )
2023	2023	SMITH-KETTLEWELL EYE RESEARCH INSTITUTE, THE	2318 FILLMORE ST	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Vision Research	000	2	8/3/2023	NON-COMPETING CONTINUATION	$394,889
														Subtotal = $394,889

Issue Date FY: 2022 ( Subtotal = $398,205 )
2022	2022	SMITH-KETTLEWELL EYE RESEARCH INSTITUTE, THE	2318 FILLMORE ST	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Vision Research	000	1	7/29/2022	NEW	$398,205
														Subtotal = $398,205

Grand Total All Awards = $1,594,639

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Stereopsis and Suppression in Strabismus and Amblyopia

Award Number: R01EY034370

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer