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Myopia and Glaucoma, Linked via Mechanotransduction Mechanisms Affecting the Ganglion Cell Complex

Award Number: R01EY034086
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Myopia and Glaucoma, Linked via Mechanotransduction Mechanisms Affecting the Ganglion Cell Complex - Project Summary/Abstract Public perception of myopia as a simple inconvenience masks its sight-threatening consequences. Even moderate levels of myopia predispose an individual to glaucoma at rates equal to a hypertensive's risk for cardiovascular disease. Yet, we lack specific diagnostic markers to identify glaucoma in myopic patients. In fact, myopic eyes can exhibit anatomical changes difficult to distinguish from glaucoma. This is alarming because half the world population is predicted to be myopic in 30 years, which will increase significantly the global prevalence of myopic glaucoma and associated visual impairment. Glaucoma is a complex neuropathy that preferentially affects the ganglion cell complex (GCC). Myopia results in significant eye growth, and appears related to glaucoma through its effect on the optic nerve head. However, the mechanisms that link myopia and glaucoma, in particular the effect of myopic growth on the GCC, remain unexplored. We hypothesize that glaucoma and myopia are linked via mechanisms that sense and respond to mechanical stimuli and affect the GCC. The long-term goal of this research is to identify the mechanisms of myopic glaucoma and explore novel neuroprotection therapeutics to prolong ganglion cell function and survival. The overall objectives in this application are to identify early 1) genetic, 2) cellular, 3) structural and 4) functional markers of glaucoma longitudinally as experimental eyes develop progressive myopia compared to eyes induced with glaucoma. The research proposed in this application is innovative because it focuses on identifying key hallmarks of glaucoma comparing unique animal models of myopia and glaucoma that mimic the prolonged exposure to sustained eye growth experienced by human myopic eyes over time, which is fundamental to understanding how glaucoma can originate from myopia. This research will have a direct positive impact as a tool to accelerate the development of novel prevention and diagnostic strategies for myopic glaucoma, and open up new research avenues for pharmacological interventions and experimental therapeutics to prevent glaucomatous impairment in myopic eyes. The proposed research is significant because is expected to provide strong evidence of the unknown nature of the myopia-glaucoma relationship, will help clinicians address the long-standing challenge of diagnosing glaucoma in myopic eyes, epidemiologists refine distribution patterns of myopic glaucoma, public health professionals develop prevention strategies and campaigns, and scientists create new research avenues for myopic glaucoma.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $347,438 )
2025	2025	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	000	3	9/19/2025	NON-COMPETING CONTINUATION	$347,438
														Subtotal = $347,438

Issue Date FY: 2024 ( Subtotal = $408,750 )
2024	2024	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	000	2	7/1/2024	NON-COMPETING CONTINUATION	$408,750
														Subtotal = $408,750

Issue Date FY: 2023 ( Subtotal = $408,750 )
2023	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	000	1	6/20/2023	NEW	$408,750
														Subtotal = $408,750

Grand Total All Awards = $1,164,938

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Myopia and Glaucoma, Linked via Mechanotransduction Mechanisms Affecting the Ganglion Cell Complex

Award Number: R01EY034086

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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