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Molecular Mechanisms of Emmetropization and Experimental Myopia at Single Cell Resolution

Award Number: R01EY033824
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Molecular Mechanisms of Emmetropization and Experimental Myopia at Single Cell Resolution - PROJECT SUMMARY More than half of the world’s population is projected to be myopic (nearsighted) by 2050, significantly raising the risk of associated vision-threatening conditions including retinal detachment, maculopathy, and glaucoma. Despite the development of several evidence-based treatments to manage myopia progression, the prevalence and complication rates continue to rise, and treatment efficacy is only partial. Experimental and clinical research shows that complex gene-environment interactions are involved in the control of the post-natal growth of the eye and its optical development, including myopia onset and progression. Research using animal models has confirmed that visual experience and retinal defocus control eye growth and the development of refractive state through the process of emmetropization. While progress has been made uncovering some of the biochemical factors associated with experimental myopia, very little is known about the underlying cellular and molecular mechanisms controlling emmetropization and myopia development. This multi-PI consortium grant brings together experienced researchers and their established experimental non- human primate model of emmetropization and myopia with an internationally recognized ocular genomics research center to perform a major investigation of the retinal, RPE, choroidal, and scleral biology of post-natal eye growth and myopia development. This project examines the functional genomics and gene-environment interactions in the refractive development of the primate eye and will identify molecular mechanisms involved in the development of myopia using single cell and bulk transcriptomics, epigenomics, and proteomics. The investigators will identify and confirm, using established bioinformatic approaches, the main components of key regulatory pathways underlying emmetropization and myopia development. These studies will provide direct evidence and a more complete understanding of the mechanisms of visually regulated eye growth and myopia and will provide the largest and most comprehensive shared resource of cellular and molecular targets to date helping develop new therapies to control eye growth and manage refractive errors. This investigation meets three of the four NEI objectives for myopia research: to investigate the biochemical pathways that regulate eye growth; to identify genes that contribute to the development of refractive errors; and will help develop new technologies for assessing or treating refractive errors.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	000	4	12/4/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $494,136 )
2025	2025	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	001	4	9/22/2025	NON-COMPETING CONTINUATION	$494,136
2025	2024	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	000	3	7/3/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $494,136

Issue Date FY: 2024 ( Subtotal = $580,561 )
2024	2024	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	000	3	8/28/2024	NON-COMPETING CONTINUATION	$580,561
														Subtotal = $580,561

Issue Date FY: 2023 ( Subtotal = $579,803 )
2023	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	001	2	8/24/2023	NON-COMPETING CONTINUATION	$579,803
2023	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	000	1	10/28/2022	NEW	$0
														Subtotal = $579,803

Issue Date FY: 2022 ( Subtotal = $600,715 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	000	1	9/20/2022	NEW	$600,715
														Subtotal = $600,715

Grand Total All Awards = $2,255,215

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Molecular Mechanisms of Emmetropization and Experimental Myopia at Single Cell Resolution

Award Number: R01EY033824

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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