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A Next Generation Outer Retinal Microphysiological System

Award Number: R01EY033331
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2022
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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A Next Generation Outer Retinal Microphysiological System - ABSTRACT The discovery of induced pluripotent stem cells (iPSCs) provided scientists with the opportunity to develop differentiated tissues from patients with inherited disease, and to use these in vitro models to study disease mechanisms and to test drug and gene-based therapeutics. However, current differentiation protocols often fail to accurately recapitulate the cellular organization present in the native tissue. For example, even state-of-the- art retinal differentiation protocols, which give rise to three dimensional retinal organoids, do not accurately recapitulate the cell-cell interactions that are present in the outer retina. Specifically, choroidal endothelial cells are rarely present and never form an organized layer beneath the RPE. Similarly, rather than forming a monolayer juxtaposed to newly developed photoreceptors, RPE cells are often found in clusters located at the edges of the neural retina. In this application we describe a program focused on the development and validation of a microphysiological system engineered to accurately recreate the complex architecture of the perfused outer retina. Specifically, we propose to combine ultra-high resolution, state-of-the-art 3D printing of retinal scaffolds, iPSC technology, and microfluidics to develop a next generation microphysiological system that recapitulates the outer retina unit. Completion of the aims outlined in this proposal will help pave the way for future studies focused on evaluating the pathophysiology of complex retinal degenerative disorders such as age-related macular degeneration and development of novel drug and gene-based therapeutics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $386,250 )
2024	2024	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Vision Research	000	3	5/22/2024	NON-COMPETING CONTINUATION	$386,250
														Subtotal = $386,250

Issue Date FY: 2023 ( Subtotal = $386,250 )
2023	2023	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Vision Research	000	2	4/6/2023	NON-COMPETING CONTINUATION	$386,250
														Subtotal = $386,250

Issue Date FY: 2022 ( Subtotal = $386,250 )
2022	2022	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Vision Research	000	1	4/27/2022	NEW	$386,250
														Subtotal = $386,250

Grand Total All Awards = $1,158,750

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A Next Generation Outer Retinal Microphysiological System

Award Number: R01EY033331

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2022

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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