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ARBi - Assessment and Rehabilitation of Binocular Sensorimotor Disorders

Award Number: R01EY032162
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2022
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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ARBi - Assessment and Rehabilitation of Binocular Sensorimotor Disorders - PROJECT SUMMARY Binocular vision relies on a synergy between sensory and motor fusional mechanisms that jointly construct a single percept of the environment from the differing images formed on the two retinae. A stereoscopic sensory representation of the environment is required for accurate binocular eye movements, which in turn are required for stereoscopic sensory vision. A failure in either component of this system, especially during development, can lead to permanent binocular vision impairment. Sensory impairments can include amblyopia, diplopia and suppression, oculomotor impairments can include strabismus and vergence insufficiency, while socio-economic sequelae include lost education, sport and job opportunities and elevated adverse health risks. The current treatments for amblyopia (occlusion and penalization) are primarily monocular and do not promote binocular perception or eye movement coordination. Similarly, treatments for strabismus do not typically address binocular perception. These limitations are at least partly due to a lack of practical methodologies for the assessment of sensory-motor function and partly due to a lack of coordinated sensory-motor therapies. Recent data show that there is significant plasticity in both sensory systems and motor systems, even in adults. Many groups are now exploring methods to promote sensory plasticity with digitally modified images in dichoptic games and movies, but considerably less attention has been directed to motor plasticity or sensory and motor plasticity together. We hypothesize that additional therapeutic gains and a lower risk of adverse side effects may be achieved with a combined sensory-motor therapeutic approach that is monitored by effective sensory-motor endpoints. We argue i) that the pace of commercialization of virtual reality therapies for anisometropic amblyopia intensifies the need simultaneously to understand sensory and oculomotor deficits in strabismic amblyopia and ii) that the high levels of recidivism following surgical intervention may benefit from combined sensorimotor rehabilitation. In Aim 1, we develop and evaluate efficient methods to measure sensory and motor deficits in people with binocular vision impairment and to provide a quantitative framework for evidence-based assessment of sensory-motor therapy. In Aim 2, we measure the impact across the visual field of strabismus on the three-dimensional representation of virtual and natural environments to understand how the distribution of naturally occurring depth statistics across the visual field may impact the development of binocular sensory and motor deficits and moderate their response to treatment. In Aim 3, we develop and evaluate feedback-based methods that aim to facilitate and maintain ocular alignment and examine the potential benefit of simultaneous sensory and motor interventions for binocular visual function. In each Aim, we employ both laboratory stimuli, because of their high level of control, and natural and virtual 3D scenes, because of their rich structure and relevance to real-world deficits. The overall goal is to demonstrate the theoretical foundation for combined sensory and motor therapeutic approaches to binocular visual dysfunction.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $372,071 )
2025	2025	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	4	1/13/2025	NON-COMPETING CONTINUATION	$372,071
														Subtotal = $372,071

Issue Date FY: 2024 ( Subtotal = $412,928 )
2024	2024	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	3	12/22/2023	NON-COMPETING CONTINUATION	$412,928
														Subtotal = $412,928

Issue Date FY: 2023 ( Subtotal = $526,148 )
2023	2023	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	002	2	4/27/2023	NON-COMPETING CONTINUATION	$0
2023	2023	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	001	2	2/13/2023	NON-COMPETING CONTINUATION	$526,148
2023	2022	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	1	2/13/2023	NEW	$0
														Subtotal = $526,148

Issue Date FY: 2022 ( Subtotal = $594,898 )
2022	2022	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Vision Research	000	1	2/1/2022	NEW	$594,898
														Subtotal = $594,898

Grand Total All Awards = $1,906,045

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ARBi - Assessment and Rehabilitation of Binocular Sensorimotor Disorders

Award Number: R01EY032162

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2022

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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