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Top-down modulation of visual processing: mechanisms and functions

Award Number: R01EY030860
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2020
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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Top-down modulation of visual processing: mechanisms and functions - PROJECT SUMMARY Even at the earliest cortical stages, visual processing is influenced by internally generated information. Top- down influence on visual processing is found in very different behavioral contexts. As a result, early visual areas are increasingly considered as “interfaces” or “blackboards” where bottom-up information is confronted to top- down representations. Yet, our knowledge on the cellular and network mechanisms by which top-down signals modulate the integrative properties of visual cortical neurons is still fragmentary. Moreover, the impact on visual processing and visual perception of the relatively small top-down modulations that were described in early visual cortices is debated. Finally, we ignore to what extent top-down modulation is flexible and can be adapted to a novel behavioral goal. Our long-term goal is to better understand the functions and mechanisms of top-down influences on early visual processing using a recent and tractable model: the modulation by sound of visual processing in V1. We have recently shown that the representation of the orientation and direction of the visual stimulus in V1 is improved in the audiovisual context, through a potentiation of the response of neurons with preferred orientations matching the orientation of the visual cue, and a suppression of the activity of neurons coding for orthogonal orientations and opposite directions. The overall objective of this application is to establish the cellular and network mechanisms, functional impact and flexibility of sound modulation on early visual pro- cessing. Our central hypotheses, based on our preliminary data, is that sound modulation in V1 results from the activation of local mechanisms controlling the orientation and direction tuning of V1 neurons, that modest im- provements of the representation of visual stimuli can improve visual perception, and that sound modulation in V1 is flexible and can be adapted to novel behavioral goals by training. The rationale for the proposed research is to better understand why, when and how internal representations bias sensory perception. To test our central hypotheses, we propose the following specific aims: 1) Determine the cellular mechanisms underpinning the orientation and direction-dependent sound modulation of V1 neurons by performing whole-cell recordings in awake mice, a technique for which our laboratory has a unique expertise; Using two-photon calcium imaging in mice performing Go/NoGo behavioral tasks, we will also 2) Determine the impact of sound modulation on the representation of the visual stimulus in V1 and on visual perception; 3) Demonstrate that sound modulation is flexible and can be adapted to a novel behavioral task though training. Our approach is innovative because we will bring to the mouse a topic so far mostly addressed in primates to benefit from functional imaging, genetic tools and our unique skill at performing whole-cell recordings in awake behaving mice. The proposed research is significant because it is expected to vertically advance our understanding on how top-down inputs adapt visual processing to the behavioral goal. Ultimately, such a knowledge will inform the pathophysiology of several de- velopmental, and degenerative disorders in which top-down control of sensory processing is impaired.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	RUTGERS, THE STATE UNIVERSITY	123 WASHINGTON ST	NEWARK	NJ	07102	ESSEX	USA	Vision Research	000	5	1/7/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $412,034 )
2024	2024	RUTGERS, THE STATE UNIVERSITY	123 WASHINGTON ST	NEWARK	NJ	07102	ESSEX	USA	Vision Research	000	5	1/16/2024	NON-COMPETING CONTINUATION	$412,034
														Subtotal = $412,034

Issue Date FY: 2023 ( Subtotal = $412,034 )
2023	2023	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	123 WASHINGTON ST STE 510	NEWARK	NJ	07102	ESSEX	USA	Vision Research	000	4	1/27/2023	NON-COMPETING CONTINUATION	$412,034
														Subtotal = $412,034

Issue Date FY: 2022 ( Subtotal = $399,673 )
2022	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	123 WASHINGTON ST STE 510	NEWARK	NJ	07102	ESSEX	USA	Vision Research	000	3	2/3/2022	NON-COMPETING CONTINUATION	$399,673
														Subtotal = $399,673

Issue Date FY: 2021 ( Subtotal = $398,612 )
2021	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	123 WASHINGTON ST STE 510	NEWARK	NJ	07102	ESSEX	USA	Vision Research	001	2	2/23/2021	NON-COMPETING CONTINUATION	$28,767
2021	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	123 WASHINGTON ST STE 510	NEWARK	NJ	07102	ESSEX	USA	Vision Research	000	2	1/22/2021	NON-COMPETING CONTINUATION	$369,845
														Subtotal = $398,612

Issue Date FY: 2020 ( Subtotal = $413,881 )
2020	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	123 WASHINGTON ST STE 510	NEWARK	NJ	07102	ESSEX	USA	Vision Research	000	1	1/27/2020	NEW	$413,881
														Subtotal = $413,881

Grand Total All Awards = $2,036,234

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Top-down modulation of visual processing: mechanisms and functions

Award Number: R01EY030860

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2020

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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