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Non-canonical GABAergic Pathways in the Visual System

Award Number: R01EY030565
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2020
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Non-canonical GABAergic Pathways in the Visual System - PROJECT SUMMARY Light is a profoundly important regulator of physiology and behavior across a wide range of organisms. Light information is relayed from the retina to the brain via glutamate released from retinal ganglion cells (RGCs) at more than 40 brain regions, with some RGCs also co-releasing peptide transmitters. Despite the prevailing dogma that all RGCs release glutamate, there have been hints that some RGCs may be GABAergic. However, the identity and function of these potentially GABAergic RGCs is completely unknown. Our recent findings indicate that a subset of the melanopsin-expressing, intrinsically photosensitive (ip)RGCs are GABAergic. This proposal will test the overarching hypothesis that GABA release from the melanopsin- expressing, intrinsically photosensitive (ip)RGCs influences non-image forming behaviors. The aims of this proposal will define the types and targets of GABAergic RGCs and their role in visual behavior using a combination of mouse genetics, channelrhodopsin-based circuit tracing, anatomy, patch clamp electrophysiology, and behavior. In addition to mapping the identity and function of GABAergic RGCs, these studies will open up new areas of research into the role of inhibitory circuits in light-driven behavior and physiology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $469,381 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Vision Research	000	5	5/24/2024	NON-COMPETING CONTINUATION	$469,381
														Subtotal = $469,381

Issue Date FY: 2023 ( Subtotal = $469,381 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Vision Research	000	4	5/22/2023	NON-COMPETING CONTINUATION	$469,381
														Subtotal = $469,381

Issue Date FY: 2022 ( Subtotal = $510,020 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Vision Research	000	3	5/27/2022	NON-COMPETING CONTINUATION	$468,103
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Vision Research	001	3	9/2/2022	SUPPLEMENT FOR EXPANSION	$41,917
														Subtotal = $510,020

Issue Date FY: 2021 ( Subtotal = $689,125 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Vision Research	001	2	9/15/2021	SUPPLEMENT FOR EXPANSION	$235,200
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Vision Research	000	2	7/2/2021	NON-COMPETING CONTINUATION	$453,925
														Subtotal = $689,125

Issue Date FY: 2020 ( Subtotal = $486,934 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Vision Research	000	1	6/25/2020	NEW	$486,934
														Subtotal = $486,934

Grand Total All Awards = $2,624,841

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Non-canonical GABAergic Pathways in the Visual System

Award Number: R01EY030565

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2020

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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