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REPRESENTATION OF FAMILIAR IMAGES IN VENTRAL STREAM VISUAL CORTEX

Award Number: R01EY030226
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2020
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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REPRESENTATION OF FAMILIAR IMAGES IN VENTRAL STREAM VISUAL CORTEX - We rely for object recognition on hierarchical processing of visual input by the ventral stream of cortical visual areas. The chain begins in low-order cortex (including area V2) where neuronal activity represents local features and terminates in inferotemporal cortex (including area TE) where neuronal activity represents global images. Neuronal function in the ventral stream is subject to alteration by visual experience. One particularly robust form of visual plasticity is familiarity suppression. Familiarity suppression can be induced in TE by allowing subjects to view the same set of images repeatedly over the course of days and weeks. At the end of the familiarization period, the mean strength of neuronal responses in TE is less for the familiar images than for novel controls. On the assumption that familiarity suppression is specific to TE, it has been thought to serve some function related to late-stage processing of the global image. Recently, however, familiarity suppression has been shown to occur even in V2, where neurons represent local features and not entire objects. On the basis of this observation, we propose that familiarity suppression, far from being specific to late-stage processing of the global image, arises from principles of unsupervised statistical learning operative at each stage of the ventral stream and expressed at each stage relative to the nature and scale of represented visual information. We will test this general idea by using semi-chronic multielectrode arrays to monitor neuronal population activity simultaneously in V2 and TE during image familiarization. Experiments under Aim 1 will test the hypothesis that familiarity suppression develops independently in V2 and is not just fed back from TE. Experiments under Aim 2 will test the hypothesis that familiarization enhances the cooperative representation of an image by neuronal populations in V2 and TE. Experiments under Aim 3 will test the idea that the synaptic alterations underlying the impact of familiarization obey a Hebbian learning rule.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Vision Research	000	3	1/10/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Vision Research	000	3	1/11/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $445,962 )
2022	2022	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Vision Research	001	3	4/4/2022	NON-COMPETING CONTINUATION	$32,182
2022	2022	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Vision Research	000	3	1/6/2022	NON-COMPETING CONTINUATION	$413,780
														Subtotal = $445,962

Issue Date FY: 2021 ( Subtotal = $443,852 )
2021	2021	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Vision Research	001	2	3/8/2021	NON-COMPETING CONTINUATION	$32,032
2021	2021	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Vision Research	000	2	1/7/2021	NON-COMPETING CONTINUATION	$411,820
														Subtotal = $443,852

Issue Date FY: 2020 ( Subtotal = $458,509 )
2020	2020	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Vision Research	000	1	12/26/2019	NEW	$458,509
														Subtotal = $458,509

Grand Total All Awards = $1,348,323

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REPRESENTATION OF FAMILIAR IMAGES IN VENTRAL STREAM VISUAL CORTEX

Award Number: R01EY030226

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2020

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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