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Data-Driven Biomechanical Simulation of Eye Movement and Strabismus

Award Number: R01EY029715
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2019
PERIOD OF PERFORMANCE END DATE: 11/30/2024

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Data-Driven Biomechanical Simulation of Eye Movement and Strabismus - SUMMARY Strabismus, a common binocular vision disorder that involves neuromuscular abnormality of the eyes, affects 18 million Americans. The disorder causes double vision, binocular confusion, eyestrain, and other symptoms that complicate daily activities. Strabismus is commonly treated surgically based on surgical intuition and tradition, but with reported disappointing success rates ranging from 30% to 80%. We propose to develop a novel data- driven modeling and simulation framework to simulate the neuro-biomechanics of strabismus that can bridge experimental studies and clinical application to advance our understanding and treatment of strabismus. We will develop the first three dimensional biomechanical model of the oculomotor system that incorporates recent findings on extraocular muscle pulleys and muscle compartments. Using clinical data from multiple individual cases as strong tests of the model, we will then develop generalized strategies for diagnosis and novel treatment for common but problematic classes (archetypes) of strabismus that require improved management. The knowledge gained from such systematic investigation can be directly applied clinically to assist future assessment and quantitative surgical dosing of similar patients without simulating every patient. The success of the proposed science-guided strabismus treatment approach could be utilized for other archetypes of strabismus as well as other oculomotor disorders to improve clinical outcomes. We will perform three sets of related analyses. In Aim 1, we will develop a novel computational model of the eyes capable of simulating binocular eye movement in three dimensions and overcoming limitations of existing models. For the first time, latest research findings on the functional compartmentalization of extraocular muscles and the actively-controlled pulley connective tissue gimbal system will be included in the biomechanical model. The developed model will be validated against empirical and clinical data so that it can be used rigorously in clinical simulation. In Aim 2 and Aim 3, we will leverage the model developed in Aim 1 to perform patient-specific strabismus simulation incorporating clinical data. The role of compartmentalization in the pathophysiology of two common types of cyclovertical strabismus, superior oblique palsy and sagging eye syndrome, will be examined. Different surgical interventions on treating these conditions will be simulated on patient-specific orbit models to assess the effectiveness of these surgical procedures. The outcome of this project will be a data-driven realistic neuro-biomechanical eye movement simulator, useful for scientific research, clinical insights, and evaluation of different types of surgical approaches to common forms of strabismus. Such a model can potentially improve our understanding of the functions of extraocular muscle compartmentalization in normal eye movements and in strabismus. It can also provide quantitative assessment of surgical intervention effectiveness and shed light on nonsurgical therapy of strabismus.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$15,934 )
2025	2022	GEORGE MASON UNIVERSITY	4400 UNIVERSITY DR	FAIRFAX	VA	22030	FAIRFAX CITY	USA	Vision Research	000	4	5/5/2025	NON-COMPETING CONTINUATION	-$15,934
														Subtotal = -$15,934

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	GEORGE MASON UNIVERSITY	4400 UNIVERSITY DR	FAIRFAX	VA	22030	FAIRFAX CITY	USA	Vision Research	000	4	8/8/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $236,069 )
2022	2022	GEORGE MASON UNIVERSITY	4400 UNIVERSITY DR	FAIRFAX	VA	22030	FAIRFAX CITY	USA	Vision Research	000	4	6/21/2022	NON-COMPETING CONTINUATION	$236,069
														Subtotal = $236,069

Issue Date FY: 2021 ( Subtotal = $411,068 )
2021	2021	GEORGE MASON UNIVERSITY	4400 UNIVERSITY DR	FAIRFAX	VA	22030	FAIRFAX CITY	USA	Vision Research	000	3	5/11/2021	NON-COMPETING CONTINUATION	$411,068
														Subtotal = $411,068

Issue Date FY: 2020 ( Subtotal = $423,781 )
2020	2020	GEORGE MASON UNIVERSITY	4400 UNIVERSITY DR	FAIRFAX	VA	22030	FAIRFAX CITY	USA	Vision Research	000	2	5/13/2020	NON-COMPETING CONTINUATION	$423,781
														Subtotal = $423,781

Issue Date FY: 2019 ( Subtotal = $450,905 )
2019	2019	GEORGE MASON UNIVERSITY	4400 UNIVERSITY DR	FAIRFAX	VA	22030	FAIRFAX CITY	USA	Vision Research	000	1	5/23/2019	NEW	$450,905
														Subtotal = $450,905

Grand Total All Awards = $1,505,889

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Data-Driven Biomechanical Simulation of Eye Movement and Strabismus

Award Number: R01EY029715

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2019

PERIOD OF PERFORMANCE END DATE: 11/30/2024

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