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Unique physiological properties of novel ganglion cell types in primate retina

Award Number: R01EY029247
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2018
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Unique physiological properties of novel ganglion cell types in primate retina - Project Summary/Abstract The overall objective of this research is to gain a deeper understanding of visual processing in the macaque monkey retina, the most important animal model for understanding human vision, and to leverage that knowledge to treat blindness. The goal of the proposed work is to determine how four poorly understood retinal cell types contribute to visual processing in primates. Many of the retinal amacrine and ganglion cell types that have been characterized in non-primate retinas perform complex and specialized visual computations, extracting information such as motion direction, object orientation, and object versus background motion from visual inputs. Whether similar computations also occur in the primate retina is unclear, because most physiological studies have focused on the role of only five of the ~20 output pathways. We have identified four cell types in the macaque monkey retina that exhibit intriguing differences from the five better-studied cell types in their visual response properties. Our specific aims are to 1) determine how striking waves of activity in the network of A1 amacrine cells network shapes the light response properties of parasol ganglion cells, 2) determine how intrinsic and circuit mechanisms shape the unusual spatial and temporal response properties of broad thorny ganglion cells, and 3) determine how membrane and receptive field properties allow ON- and OFF-type smooth monostratified ganglion cells to signal distinct information to the brain from their parasol cell counterparts. At the conclusion of this work, we expect to have a deeper understanding of the visual computations performed by the primate retina and the neural mechanisms that underlie those computations. Further, this project will shed much needed light on how retinal processing in primates, and by extension humans, relates to that observed in rodents and other animal models.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $587,505 )
2026	2026	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	8	4/6/2026	NON-COMPETING CONTINUATION	$587,505
														Subtotal = $587,505

Issue Date FY: 2025 ( Subtotal = $598,283 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	7	3/13/2025	NON-COMPETING CONTINUATION	$598,283
														Subtotal = $598,283

Issue Date FY: 2024 ( Subtotal = $607,177 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	002	6	4/19/2024	NON-COMPETING CONTINUATION	$607,177
2024	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	001	5	1/16/2024	COMPETING CONTINUATION	$3,483
2024	2021	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	4	1/16/2024	NON-COMPETING CONTINUATION	-$3,483
														Subtotal = $607,177

Issue Date FY: 2023 ( Subtotal = $625,496 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	5	2/2/2023	COMPETING CONTINUATION	$625,496
2023	2021	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	001	4	2/6/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $625,496

Issue Date FY: 2021 ( Subtotal = $530,985 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	4	6/17/2021	NON-COMPETING CONTINUATION	$530,985
														Subtotal = $530,985

Issue Date FY: 2020 ( Subtotal = $555,207 )
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	3	6/22/2020	NON-COMPETING CONTINUATION	$555,207
														Subtotal = $555,207

Issue Date FY: 2019 ( Subtotal = $562,686 )
2019	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	001	2	8/5/2019	NON-COMPETING CONTINUATION	$562,686
2019	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	1	11/15/2018	NEW	$0
														Subtotal = $562,686

Issue Date FY: 2018 ( Subtotal = $598,962 )
2018	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	1	9/21/2018	NEW	$598,962
														Subtotal = $598,962

Grand Total All Awards = $4,666,301

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Unique physiological properties of novel ganglion cell types in primate retina

Award Number: R01EY029247

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2018

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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