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Retinal Circuitry

Award Number: R01EY028927
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2019
PERIOD OF PERFORMANCE END DATE: 08/01/2025

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Retinal Circuitry - EY028927 Retinal Circuitry Project Summary Abstract This grant is constructed around 3 simple conceptual questions, with 3 speciﬁc aims generated around studying retinal circuity and how that circuitry changes in disease. The last grant period responded to a strategic goal of the NEI, and funded infrastructure and the creation of a set of connectomes to explore retinal wiring and serve as a resource for future work in pathoconnectomes for those model systems from early retinal degeneration to late retinal degeneration. Connectomes that derived from that work are a mouse retinal connectome RC2, and a non-human primate retinal connectome RC3, that are the largest, and highest resolution retinal connectomes now on Earth, encompassing all of the resolution required to resolve synapses, gap junctions, adherens junctions and more. Speciﬁc Aim 1 will explore the comparative anatomy of retinal circuit topologies from mouse, to rabbit, to non-human primate, focusing initially upon well understood retinal circuit topologies that we have worked out in rabbit such as the Aii amacrine cell, but expanding to other retinal cell classes and network topologies including directional selectivity. Speciﬁc Aim 2 proposes to build 3 new pathoconnectomes from non-human primate models of retinal disease including AMD, optic nerve atrophy, and achromatopsia, and initiate annotation in those databases, continuing the successful work initiated in the last award period with the hypothesis that the ultrastructure of neuronal circuit topology in degenerative disease points to stereotyped connections that reveal targets for therapies not just in mice and rabbits, but also in non-human primate models relevant to human disease. Speciﬁc Aim 3 will map proteins from the progressive stages of retinal degeneration in rabbit models of retinal degeneration, and virtually map them into ultrastructural space of our existing connectomes and pathoconnectomes. These changes in proteins reﬂect alterations in the pharmacology, morphology, metabolism, and functional circuitry that suggest additional targets for therapeutic intervention, revealed by speciﬁc protein expression and localizations, informative as to mechanisms associated with retinal degeneration and remodeling. Proteins serve as mediators of cell/cell communication and contact and their inclusion in retinal connectomes will facilitate the fundamentals of modeling.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $672,791 )
2026	2026	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Vision Research	001	7	8/18/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$672,791
2026	2025	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	002	6	8/26/2026	COMPETING CONTINUATION	$0
2026	2025	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	000	6	8/12/2026	COMPETING CONTINUATION	$0
														Subtotal = $672,791

Issue Date FY: 2025 ( Subtotal = $685,322 )
2025	2025	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	000	6	3/13/2025	COMPETING CONTINUATION	$685,322
2025	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	001	5	5/15/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $685,322

Issue Date FY: 2023 ( Subtotal = $682,261 )
2023	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	000	5	3/23/2023	NON-COMPETING CONTINUATION	$682,261
														Subtotal = $682,261

Issue Date FY: 2022 ( Subtotal = $976,496 )
2022	2022	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	002	4	8/22/2022	SUPPLEMENT FOR EXPANSION	$298,808
2022	2022	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	000	4	12/15/2021	NON-COMPETING CONTINUATION	$628,783
2022	2022	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	001	4	1/27/2022	NON-COMPETING CONTINUATION	$48,905
														Subtotal = $976,496

Issue Date FY: 2021 ( Subtotal = $691,547 )
2021	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	001	3	2/23/2021	NON-COMPETING CONTINUATION	$49,905
2021	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	000	3	1/26/2021	NON-COMPETING CONTINUATION	$641,642
														Subtotal = $691,547

Issue Date FY: 2020 ( Subtotal = $726,748 )
2020	2020	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	001	2	1/31/2020	NON-COMPETING CONTINUATION	$72,675
2020	2020	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	000	2	12/16/2019	NON-COMPETING CONTINUATION	$654,073
														Subtotal = $726,748

Issue Date FY: 2019 ( Subtotal = $741,998 )
2019	2019	UNIVERSITY OF UTAH, THE	201 S PRESIDENT CIRCLE RM 408	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Vision Research	000	1	12/27/2018	NEW	$741,998
														Subtotal = $741,998

Grand Total All Awards = $5,177,163

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Retinal Circuitry

Award Number: R01EY028927

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2019

PERIOD OF PERFORMANCE END DATE: 08/01/2025

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