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Continuous measurement and control of intraocular pressure in normal and glaucomatous eyes

Award Number: R01EY027037
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Continuous measurement and control of intraocular pressure in normal and glaucomatous eyes - PROJECT SUMMARY Regulation of intraocular pressure (IOP) is a subject of considerable scientific, clinical, and pharmaceutical interest. High IOP is an established risk factor for glaucoma, an insidious disease that causes blindness by killing retinal ganglion cells, so lowering IOP is a primary focus of all current treatments. The first approach in clinical care is to prescribe patients medicines that alter the production and outflow of aqueous fluid in the eye. Many of these medicines achieve a therapeutic effect by targeting signals from the autonomic nervous system, which dynamically modulates aqueous humor dynamics for reasons that are not entirely known. One of the strongest modulators is the suprachiasmatic nucleus in the brain, which coordinates a circadian rhythm in mean IOP. Other autonomic neuromodulators include stress and intracranial pressure (ICP). Their collective actions cause IOP to fluctuate continually, sometimes reaching levels that would cause glaucoma in some individuals if maintained for extended periods. Involvement of ICP in IOP modulation is particularly intriguing because ICP contributes to the translaminar pressure gradient across the optic nerve head, which determines the mechanical stress and strain profiles experienced by retinal ganglion cell axons as they exit the eye to the brain. ICP could therefore factor into glaucoma pathophysiology as well. The proposed research is directed at advancing our understanding of circadian and autonomic mechanisms of IOP modulation and the potential involvement of these mechanisms in disease onset and progression. To do this, one-of-a-kind technologies are used that provide researchers the ability to record or control IOP or ICP round-the-clock in rats. IOP, ICP, body temperature, locomotor activity, aqueous outflow facility, and ocular compliance will be concurrently recorded in various combinations as ambient light-dark cycle is altered, sympathetic nerve agonists and antagonists are administered, and variable pressure loads are transiently applied to the eye. In so doing, new insights will be gained about the origin and control of ocular rhythms, about efferent control of IOP by ICP, and about possible roles of circadian and autonomic systems in glaucoma. These insights could lead to new approaches and targets for disease treatment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Vision Research	000	8	1/27/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $375,000 )
2025	2025	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Vision Research	001	9	5/30/2025	COMPETING CONTINUATION	$375,000
2025	2024	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Vision Research	000	8	5/23/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $375,000

Issue Date FY: 2024 ( Subtotal = $355,467 )
2024	2024	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Vision Research	000	8	1/26/2024	NON-COMPETING CONTINUATION	$355,467
														Subtotal = $355,467

Issue Date FY: 2023 ( Subtotal = $356,500 )
2023	2023	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Vision Research	000	7	1/27/2023	NON-COMPETING CONTINUATION	$356,500
														Subtotal = $356,500

Issue Date FY: 2022 ( Subtotal = $346,739 )
2022	2022	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Vision Research	002	6	2/4/2022	NON-COMPETING CONTINUATION	$346,739
2022	2021	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Vision Research	001	5	1/24/2022	COMPETING CONTINUATION	$49,005
2022	2019	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Vision Research	000	4	1/24/2022	NON-COMPETING CONTINUATION	-$49,005
														Subtotal = $346,739

Issue Date FY: 2021 ( Subtotal = $358,389 )
2021	2021	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Vision Research	001	5	1/15/2021	COMPETING CONTINUATION	$358,389
2021	2019	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Vision Research	000	4	1/14/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $358,389

Issue Date FY: 2019 ( Subtotal = $355,158 )
2019	2019	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Vision Research	000	4	7/18/2019	NON-COMPETING CONTINUATION	$355,158
														Subtotal = $355,158

Issue Date FY: 2018 ( Subtotal = $356,210 )
2018	2018	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Vision Research	000	3	9/7/2018	NON-COMPETING CONTINUATION	$356,210
														Subtotal = $356,210

Issue Date FY: 2017 ( Subtotal = $357,203 )
2017	2017	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVE	TAMPA	FL	33620	HILLSBOROUGH	USA	Vision Research	000	2	8/14/2017	NON-COMPETING CONTINUATION	$357,203
														Subtotal = $357,203

Issue Date FY: 2016 ( Subtotal = $358,140 )
2016	2016	UNIVERSITY OF SOUTH FLORIDA	4202 E FOWLER AVENUE	TAMPA	FL	33620	HILLSBOROUGH	USA	Vision Research	000	1	7/20/2016	NEW	$358,140
														Subtotal = $358,140

Grand Total All Awards = $3,218,806

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Continuous measurement and control of intraocular pressure in normal and glaucomatous eyes

Award Number: R01EY027037

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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