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Mechanisms of Early Functional Loss in Diabetic Eye Disease

Award Number: R01EY026004
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2015
PERIOD OF PERFORMANCE END DATE: 03/31/2030

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Mechanisms of Early Functional Loss in Diabetic Eye Disease - PROJECT SUMMARY Although there is growing consensus that diabetic retinal neurodegeneration (DRN) can precede clinically-apparent vascular abnormalities and may eventually be useful for staging diabetic retinopathy (DR), there is no agreement regarding how DRN is defined, staged, or which measures best reflect neural dysfunction in these individuals. Work completed during prior funding cycles, supported by other researchers, has shown that electrophysiological, psychophysical, and pupillometric approaches can provide sensitive, non-invasive, and quantifiable measures of DRN. However, prior studies that have measured functional consequences of DRN have generally been cross-sectional and performed under typical light- adapted clinical conditions. These studies provide little insight into important challenges reported by individuals with DR, including functioning under dim illumination and adjusting to changing illumination conditions. To address these limitations, we propose to develop and apply novel tools and approaches capable of characterizing the nature and extent of visual dysfunction and its relationship to DRN in individuals with mild or no DR (M/N DR). These approaches will evaluate visual function across a wide range of lighting conditions typical of daily life, assess the ability to adjust to changing illumination conditions, and will be performed longitudinally. Three complementary aims are proposed that use non-invasive tools to provide new views of retinal function under broad and varying levels of illumination: Aim 1 will define key pathophysiological changes in rod, cone, and post-receptor function in M/N DR; Aim 2 will develop and apply a battery of electrophysiological techniques to identify photoreceptor and downstream post-receptor dysfunction; Aim 3 will determine how M/N DR affects non-image- forming pathways. We will determine whether functional measures targeting the inner- or outer- retina show greater DRN progression and if either predicts ETDRS stage advancement. Completing these Aims will: 1) provide a novel framework using complementary approaches for assessing visual dysfunction and the underlying mechanisms in M/N DR, 2) introduce new tools and functional assays that can provide clinically-relevant indices of DRN that address common visual complaints of DR subjects, 3) permit comparisons among measures to define optimal tests of DRN with high diagnostic power. We expect these studies to drive significant advances in clinical DR staging and understanding of early neural deficits.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $437,062 )
2026	2026	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Vision Research	001	10	4/1/2026	NON-COMPETING CONTINUATION	$437,062
2026	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Vision Research	000	8	11/17/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $437,062

Issue Date FY: 2025 ( Subtotal = $437,062 )
2025	2025	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Vision Research	000	9	7/23/2025	COMPETING CONTINUATION	$437,062
														Subtotal = $437,062

Issue Date FY: 2023 ( Subtotal = $587,219 )
2023	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Vision Research	001	8	5/1/2023	NON-COMPETING CONTINUATION	$399,750
2023	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Vision Research	000	7	4/26/2023	SUPPLEMENT FOR EXPANSION	$187,469
														Subtotal = $587,219

Issue Date FY: 2022 ( Subtotal = $387,758 )
2022	2022	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Vision Research	001	7	5/20/2022	NON-COMPETING CONTINUATION	$387,758
2022	2020	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Vision Research	000	5	12/27/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $387,758

Issue Date FY: 2021 ( Subtotal = $399,750 )
2021	2021	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Vision Research	001	6	4/16/2021	COMPETING CONTINUATION	$399,750
2021	2020	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Vision Research	000	5	4/12/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $399,750

Issue Date FY: 2020 ( Subtotal = $399,750 )
2020	2020	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Vision Research	001	5	1/29/2020	NON-COMPETING CONTINUATION	$39,975
2020	2020	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Vision Research	000	5	12/4/2019	NON-COMPETING CONTINUATION	$359,775
														Subtotal = $399,750

Issue Date FY: 2019 ( Subtotal = $399,750 )
2019	2019	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Vision Research	000	4	12/3/2018	NON-COMPETING CONTINUATION	$399,750
														Subtotal = $399,750

Issue Date FY: 2018 ( Subtotal = $399,750 )
2018	2018	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Vision Research	000	3	11/20/2017	NON-COMPETING CONTINUATION	$359,775
2018	2018	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Vision Research	001	3	6/1/2018	NON-COMPETING CONTINUATION	$39,975
														Subtotal = $399,750

Issue Date FY: 2017 ( Subtotal = $399,750 )
2017	2017	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Vision Research	001	2	8/10/2017	NON-COMPETING CONTINUATION	$39,975
2017	2017	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Vision Research	000	2	12/5/2016	NON-COMPETING CONTINUATION	$359,775
														Subtotal = $399,750

Issue Date FY: 2016 ( Subtotal = $387,636 )
2016	2016	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Vision Research	000	1	11/30/2015	NEW	$387,636
														Subtotal = $387,636

Grand Total All Awards = $4,235,487

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Mechanisms of Early Functional Loss in Diabetic Eye Disease

Award Number: R01EY026004

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2015

PERIOD OF PERFORMANCE END DATE: 03/31/2030

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