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Functional-neuroanatomy of high-level visual cortex: a quantitative multimodal approach

Award Number: R01EY023915
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2014
PERIOD OF PERFORMANCE END DATE: 01/31/2029

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Functional-neuroanatomy of high-level visual cortex: a quantitative multimodal approach - PROJECT SUMMARY Humans rapidly comprehend the continuous visual input - perceiving who are the people, what are their actions, and where are they. These percepts emerge from computations across ventral, lateral, dorsal streams, respectively. However, it is unknown how the interplay between brain structure, function, and computation supports these visual behaviors. Leveraging advancements from the prior funding period, we propose a unique multimodal and computational approach to answer this question. The research will focus on ventral and lateral streams, as the ventral is the most understood and the lateral is the least understood. Aim 1 will elucidate the interplay between function, white matter connections, and cytoarchitecture using functional, anatomical, and diffusion MRI, as well as cytoarchitectonic data. We will quantitatively measure the relation between functional and structural data, develop computational models linking these metrics, and evaluate their predictivity in left out data. Aim 2 will determine the nature of basic spatiotemporal computations in the visual system and how they affect visual capacity. Aim 2a, will use fMRI and novel spatiotemporal population receptive field (ST-pRF) modeling to determine how basic spatiotemporal computations vary with stimuli and attention. Aim 2b, will use fMRI and behavioral measurements to measure neural and visual capacity, respectively, to multiple stimuli presented sequentially or simultaneously under different attention conditions. Using ST-pRFs, we will determine what spatiotemporal computations predict neural capacity, and then develop a linking model predicting from brain responses visual capacity. Aim 3 will use exciting new topographic deep neural networks (TDANNs) together with massive fMRI datasets of brain responses to visual stimuli to determine how behavioral goals and structural constraints affect the function and spatial organization of the human visual system. This will not only shed important light into the utility of implementational factors, but also generate a single model linking structure, function, and visual behavior. The research will (i) significantly advance understanding of the interplay between visual function, structure, and computations in multiple visual streams filling in longstanding empirical and theoretical gaps, (ii) generate new computational and theoretical understanding how basic spatiotemporal computations and structural constraints affect visual processing, and (iii) generate innovative open source empirical and computational methodologies. This research has important health ramifications for developing noninvasive diagnostics for clinical conditions associated with malfunction of high-level visual cortex including prosopagnosia, action agnosia, and dyslexia, and will provide a new computational testing bed for developing cortical visual prosthetics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $565,095 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	002	10	6/11/2025	COMPETING CONTINUATION	$3
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	10	12/27/2024	COMPETING CONTINUATION	$565,095
2025	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	001	9	6/11/2025	SUPPLEMENT FOR EXPANSION	-$3
														Subtotal = $565,095

Issue Date FY: 2024 ( Subtotal = $102,650 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	9	12/14/2023	SUPPLEMENT FOR EXPANSION	$102,650
														Subtotal = $102,650

Issue Date FY: 2023 ( Subtotal = $390,500 )
2023	2023	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	9	1/23/2023	NON-COMPETING CONTINUATION	$390,500
														Subtotal = $390,500

Issue Date FY: 2022 ( Subtotal = $378,785 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	8	1/20/2022	NON-COMPETING CONTINUATION	$378,785
														Subtotal = $378,785

Issue Date FY: 2021 ( Subtotal = $379,064 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	7	2/22/2021	NON-COMPETING CONTINUATION	$379,064
														Subtotal = $379,064

Issue Date FY: 2020 ( Subtotal = $385,595 )
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	003	6	6/12/2020	COMPETING CONTINUATION	$119
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	001	6	1/23/2020	COMPETING CONTINUATION	$385,595
2020	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	5	1/15/2020	NON-COMPETING CONTINUATION	$0
2020	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	002	5	6/12/2020	NON-COMPETING CONTINUATION	-$119
														Subtotal = $385,595

Issue Date FY: 2018 ( Subtotal = $387,819 )
2018	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	5	5/22/2018	NON-COMPETING CONTINUATION	$387,819
														Subtotal = $387,819

Issue Date FY: 2017 ( Subtotal = $387,819 )
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	4	6/19/2017	NON-COMPETING CONTINUATION	$387,819
														Subtotal = $387,819

Issue Date FY: 2016 ( Subtotal = $387,819 )
2016	2016	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	3	6/28/2016	NON-COMPETING CONTINUATION	$387,819
														Subtotal = $387,819

Issue Date FY: 2015 ( Subtotal = $380,062 )
2015	2015	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	2	5/14/2015	NON-COMPETING CONTINUATION	$380,062
														Subtotal = $380,062

Issue Date FY: 2014 ( Subtotal = $381,769 )
2014	2014	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	1	6/1/2014	NEW	$381,769
														Subtotal = $381,769

Grand Total All Awards = $4,126,977

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Functional-neuroanatomy of high-level visual cortex: a quantitative multimodal approach

Award Number: R01EY023915

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2014

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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