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Organization and Function of Visual Cortical Feedback Systems

Award Number: R01EY022577
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2012
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Organization and Function of Visual Cortical Feedback Systems - Project Summary Visual perception is mediated by complex interactions amongst neurons in the retina, visual cortex, and subcortical brain structures. The importance of vision to humans and other primates is reflected in the enormous percentage of cerebral cortex devoted to processing visual information. Thus, deficits in visual processing are particularly debilitating and arise from abnormalities not only in the eye, but also in cortical and subcortical circuitry. For example, strabismus or amblyopia during childhood can have long-lasting effects on the cortical circuits that process visual information. There is also evidence that some forms of dyslexia result from central visual system abnormalities. The function of the nervous system is dependent on complex interactions between networks of neurons composed of multiple neuron types across multiple cortical and subcortical areas. General principles about cortical feedback connections and corticothalamic networks learned from studies of the mouse visual system are likely to also apply to circuits mediating cognitive functions and may be impaired in disorders such as autism and schizophrenia. The proposed studies are aimed at revealing the organization and functional impact of: 1) cortical feedback connections to the primary visual cortex; and 2) cortico-thalamo-cortical circuits. These studies are conducted in mice to take advantage of the range of molecular, genetic, and viral tools that can be used to elucidate brain circuits and link them to function using optogenetic and imaging methods. The 4 aims will reveal: 1) the functional impact of feedback from layers 2/3 or layer 5 of cortical areas AL and PM to V1; 2) how feedback from layers 2/3 or layer 5 of cortical areas AL and PM to V1 integrate with specific inhibitory circuits within V1; 3) the input-output relationships of neurons in the pulvinar nucleus of the thalamus that project to identified visual cortical areas; 4) the functional impact of pulvinar inputs to the visual cortex.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $583,028 )
2025	2025	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	000	13	5/14/2025	NON-COMPETING CONTINUATION	$583,028
														Subtotal = $583,028

Issue Date FY: 2024 ( Subtotal = $583,028 )
2024	2024	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	000	12	5/22/2024	NON-COMPETING CONTINUATION	$583,028
														Subtotal = $583,028

Issue Date FY: 2023 ( Subtotal = $584,327 )
2023	2023	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	001	11	5/26/2023	COMPETING CONTINUATION	$583,028
2023	2023	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	004	11	9/18/2023	COMPETING CONTINUATION	$1,299
2023	2021	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	002	10	9/18/2023	NON-COMPETING CONTINUATION	-$1,200
2023	2021	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	000	10	4/24/2023	SUPPLEMENT FOR EXPANSION	$1,299
2023	2021	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	003	10	9/18/2023	SUPPLEMENT FOR EXPANSION	-$99
														Subtotal = $584,327

Issue Date FY: 2021 ( Subtotal = $564,678 )
2021	2021	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	000	10	9/1/2021	NON-COMPETING CONTINUATION	$522,685
2021	2021	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	001	10	9/2/2021	SUPPLEMENT FOR EXPANSION	$41,993
														Subtotal = $564,678

Issue Date FY: 2020 ( Subtotal = $642,755 )
2020	2020	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	000	9	7/20/2020	NON-COMPETING CONTINUATION	$642,755
														Subtotal = $642,755

Issue Date FY: 2019 ( Subtotal = $674,503 )
2019	2019	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	000	7	6/21/2019	SUPPLEMENT FOR EXPANSION	$31,748
2019	2019	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	001	8	7/17/2019	NON-COMPETING CONTINUATION	$642,755
														Subtotal = $674,503

Issue Date FY: 2018 ( Subtotal = $538,851 )
2018	2018	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	000	7	7/23/2018	NON-COMPETING CONTINUATION	$538,851
														Subtotal = $538,851

Issue Date FY: 2017 ( Subtotal = $485,000 )
2017	2017	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	002	6	9/19/2017	COMPETING CONTINUATION	$485,000
2017	2016	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	003	5	9/23/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
2017	2016	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	001	5	12/27/2016	EXTENSION WITH OR WITHOUT FUNDS	$63,841
2017	2015	SALK INSTITUTE FOR BIOLOGICAL STUDIES, SAN DIEGO, CALIFORNIA, THE	10010 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Vision Research	000	4	12/27/2016	NON-COMPETING CONTINUATION	-$63,841
														Subtotal = $485,000

Issue Date FY: 2016 ( Subtotal = $558,557 )
2016	2016	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Vision Research	000	5	4/19/2016	EXTENSION WITH OR WITHOUT FUNDS	$558,557
														Subtotal = $558,557

Issue Date FY: 2015 ( Subtotal = $547,384 )
2015	2015	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Vision Research	000	4	5/4/2015	NON-COMPETING CONTINUATION	$547,384
														Subtotal = $547,384

Issue Date FY: 2014 ( Subtotal = $547,386 )
2014	2014	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Vision Research	000	3	6/9/2014	NON-COMPETING CONTINUATION	$547,386
														Subtotal = $547,386

Issue Date FY: 2013 ( Subtotal = $530,628 )
2013	2013	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Vision Research	001	2	6/12/2013	NON-COMPETING CONTINUATION	$27,928
2013	2013	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Vision Research	000	2	5/2/2013	NON-COMPETING CONTINUATION	$502,700
														Subtotal = $530,628

Issue Date FY: 2012 ( Subtotal = $597,437 )
2012	2012	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Vision Research	001	1	9/4/2012	SUPPLEMENT FOR EXPANSION	$38,880
2012	2012	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Vision Research	000	1	4/23/2012	NEW	$558,557
														Subtotal = $597,437

Grand Total All Awards = $7,437,562

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Organization and Function of Visual Cortical Feedback Systems

Award Number: R01EY022577

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2012

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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