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Adaptive high-resolution electrical stimulation for retinal implant design

Award Number: R01EY021271
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2011
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Adaptive high-resolution electrical stimulation for retinal implant design - Project Summary/Abstract The goal of our work is to develop a high-resolution electronic epiretinal implant for treating incurable blindness from retinal degeneration. To further this goal, we propose here to develop novel techniques for adaptive, high-resolution, multi-electrode recording and stimulation of retinal ganglion cells (RGCs) in the isolated macaque and human retina as an experimental lab prototype for the future device. The major goals of this project are to (1) adaptively use current steering with electrode triplets to enhance selective targeting of RGCs, (2) adaptively use spatio-temporal dithering and multiplexing to produce naturalistic activity in large RGC populations that can support high-quality visual coding, and (3) test the fidelity of electrically evoked visual signals in RGCs of the central human retina. Tackling these aims will allow us to emulate the neural code for vision, cell-by-cell and spike-by-spike, over a region of the central retina. Our unique technical approach involves large-scale, high-resolution electrical recording and stimulation, combined with novel computational approaches to adjust device function to the complex circuitry in which it is embedded, including the degenerated retina, and thus to optimize vision restoration.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $328,333 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	12	4/4/2025	NON-COMPETING CONTINUATION	$328,333
														Subtotal = $328,333

Issue Date FY: 2024 ( Subtotal = $403,349 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	11	6/14/2024	COMPETING CONTINUATION	$403,349
														Subtotal = $403,349

Issue Date FY: 2022 ( Subtotal = -$129 )
2022	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	10	9/19/2022	NON-COMPETING CONTINUATION	-$129
														Subtotal = -$129

Issue Date FY: 2020 ( Subtotal = $383,200 )
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	10	3/11/2020	NON-COMPETING CONTINUATION	$383,200
														Subtotal = $383,200

Issue Date FY: 2019 ( Subtotal = $383,200 )
2019	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	9	3/25/2019	NON-COMPETING CONTINUATION	$383,200
														Subtotal = $383,200

Issue Date FY: 2018 ( Subtotal = $383,200 )
2018	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	8	4/9/2018	NON-COMPETING CONTINUATION	$383,200
														Subtotal = $383,200

Issue Date FY: 2017 ( Subtotal = $362,874 )
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	003	7	8/7/2017	COMPETING CONTINUATION	$65,800
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	001	7	3/23/2017	COMPETING CONTINUATION	$362,874
2017	2015	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	6	3/20/2017	NON-COMPETING CONTINUATION	$0
2017	2015	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	002	6	8/7/2017	NON-COMPETING CONTINUATION	-$65,800
														Subtotal = $362,874

Issue Date FY: 2015 ( Subtotal = $378,460 )
2015	2015	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	000	6	8/19/2015	NON-COMPETING CONTINUATION	$378,460
														Subtotal = $378,460

Issue Date FY: 2014 ( Subtotal = $378,879 )
2014	2014	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	002	5	7/18/2014	NON-COMPETING CONTINUATION	$378,879
2014	2013	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Vision Research	000	3	5/5/2014	NON-COMPETING CONTINUATION	-$275,665
2014	2013	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Vision Research	001	4	5/5/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$275,665
														Subtotal = $378,879

Issue Date FY: 2013 ( Subtotal = $424,710 )
2013	2013	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Vision Research	000	3	7/30/2013	NON-COMPETING CONTINUATION	$424,710
														Subtotal = $424,710

Issue Date FY: 2012 ( Subtotal = $438,814 )
2012	2012	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Vision Research	001	2	9/5/2012	NON-COMPETING CONTINUATION	$436,252
2012	2011	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Vision Research	000	1	7/16/2012	NEW	$2,562
														Subtotal = $438,814

Issue Date FY: 2011 ( Subtotal = $436,291 )
2011	2011	SALK INSTITUTE FOR BIOLOGICAL STUDIES	P.O. BOX 85800	SAN DIEGO	CA	92186	SAN DIEGO	USA	Vision Research	000	1	8/1/2011	NEW	$436,291
														Subtotal = $436,291

Grand Total All Awards = $4,301,181

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Adaptive high-resolution electrical stimulation for retinal implant design

Award Number: R01EY021271

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2011

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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