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Development of direction selectivity in retina

Award Number: R01EY019498
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2009
PERIOD OF PERFORMANCE END DATE: 11/30/2026

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Development of direction selectivity in retina - The development of neural circuits involves a rich interplay between molecular cues and neural activity. This is perhaps most well studied in the visual system, where several molecular interactions have been identified as being critical for early establishment of coarse visual maps while both early spontaneous activity called retinal waves prior to eye opening and visual deprivation after eye opening leads to map refinement. We study this question in a direction-selective ganglion cells of the retina. Direction selective ganglion cells respond strongly to an image moving in the preferred direction and weakly to an image moving in the opposite, or null direction. Direction-selective ganglion cells are critical for driving ocular-motor reflexes that stabilize images on the retina as we move through a visual scene as well as for sensing the movement of objects within the visual scene. The preferred directions of direction selective ganglion cells cluster along four directions that align along two optic flow axes, an organization we refer to as the direction selectivity map. The mechanisms that instruct the development of this direction selectivity map are unknown. Here we propose to use a combination of state-of-the-art two-photon calcium imaging, electrophysiology, and transgenic mouse strategies to determine the mechanisms that underlie the development of the direction selectivity maps. In particular, we will determine if neural signaling, either through gap junctions or retinal waves, play a critical role in the formation of these direction selectivity maps. Finally, we will test candidate synaptogenic molecules identified in an RNA-seq screen that may instruct the emergence of the functional inhibitory synapses that underlie direction selective responses.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $391,078 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	16	11/25/2024	NON-COMPETING CONTINUATION	$391,078
														Subtotal = $391,078

Issue Date FY: 2024 ( Subtotal = $391,078 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	15	11/29/2023	NON-COMPETING CONTINUATION	$391,078
														Subtotal = $391,078

Issue Date FY: 2023 ( Subtotal = $536,931 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	002	14	2/10/2023	SUPPLEMENT FOR EXPANSION	$145,853
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	001	14	1/6/2023	NON-COMPETING CONTINUATION	$351,970
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	003	14	3/8/2023	NON-COMPETING CONTINUATION	$39,108
2023	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	12	12/8/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $536,931

Issue Date FY: 2022 ( Subtotal = $406,243 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	13	11/26/2021	COMPETING CONTINUATION	$357,983
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	001	13	9/19/2022	COMPETING CONTINUATION	$48,260
														Subtotal = $406,243

Issue Date FY: 2021 ( Subtotal = $360,633 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	001	12	2/23/2021	NON-COMPETING CONTINUATION	$26,025
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	12	11/19/2020	NON-COMPETING CONTINUATION	$334,608
														Subtotal = $360,633

Issue Date FY: 2020 ( Subtotal = $372,390 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	11	11/22/2019	NON-COMPETING CONTINUATION	$335,151
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	001	11	1/27/2020	NON-COMPETING CONTINUATION	$37,239
														Subtotal = $372,390

Issue Date FY: 2019 ( Subtotal = $372,976 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	10	11/15/2018	NON-COMPETING CONTINUATION	$372,976
														Subtotal = $372,976

Issue Date FY: 2018 ( Subtotal = $373,545 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	002	9	5/3/2018	NON-COMPETING CONTINUATION	$37,355
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	001	9	11/28/2017	NON-COMPETING CONTINUATION	$336,190
2018	2016	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	8	11/17/2017	COMPETING CONTINUATION	$0
														Subtotal = $373,545

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	7	1/21/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $374,097 )
2016	2016	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	8	7/7/2016	COMPETING CONTINUATION	$374,097
														Subtotal = $374,097

Issue Date FY: 2015 ( Subtotal = $361,414 )
2015	2015	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	7	6/8/2015	NON-COMPETING CONTINUATION	$361,414
														Subtotal = $361,414

Issue Date FY: 2014 ( Subtotal = $361,414 )
2014	2014	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	6	6/9/2014	NON-COMPETING CONTINUATION	$361,414
														Subtotal = $361,414

Issue Date FY: 2013 ( Subtotal = $350,350 )
2013	2013	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	5	6/25/2013	NON-COMPETING CONTINUATION	$350,350
														Subtotal = $350,350

Issue Date FY: 2012 ( Subtotal = $538,790 )
2012	2012	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	001	4	9/3/2012	SUPPLEMENT FOR EXPANSION	$170,000
2012	2012	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	4	6/28/2012	NON-COMPETING CONTINUATION	$368,790
														Subtotal = $538,790

Issue Date FY: 2011 ( Subtotal = $368,790 )
2011	2011	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Vision Research	000	3	6/28/2011	COMPETING CONTINUATION	$368,790
														Subtotal = $368,790

Issue Date FY: 2010 ( Subtotal = $318,914 )
2010	2010	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Trans-NIH Recovery Act Research Support	000	2	8/23/2010	NON-COMPETING CONTINUATION	$318,914
														Subtotal = $318,914

Issue Date FY: 2009 ( Subtotal = $350,836 )
2009	2009	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Trans-NIH Recovery Act Research Support	000	1	6/17/2009	NEW	$350,836
														Subtotal = $350,836

Grand Total All Awards = $6,229,479

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Development of direction selectivity in retina

Award Number: R01EY019498

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2009

PERIOD OF PERFORMANCE END DATE: 11/30/2026

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