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Neurophysiological Effects of Training in Visual Cognitive Tasks

Award Number: R01EY017077
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY The study will investigate the neural mechanisms through which visual information is maintained in working memory. The neural basis of working memory has been a matter of debate in recent years, with competing theories proposing alternative neural correlates for its maintenance. Neurophysiological recordings will target multiple subdivisions of the prefrontal cortex, a brain area implicated in working memory tasks, as well as the anterior cingulate cortex, which has been implicated in learning to perform such tasks. Monkeys will be trained in cognitive tasks that require them to observe and remember the identity of different visual objects, which can be manipulated parametrically. A chronic array of microelectrodes will be implanted, and spike and local field potential recordings will be acquired as the animals are trained to perform the working memory task, and as they learn to perform the task with different stimulus sets. The experiment will allow us to determine the patterns of neuronal activation that determine the behavioral performance in the task and adjudicate between competing models. Analysis will determine changes at the level of single neurons, and neuronal populations, as well as changes evident in the rhythmicity of local field potentials. The experiments will also uncover the nature of changes that take place in the prefrontal cortex during training to perform an object working memory task and uncover what aspects of neural activity are critical for task acquisition. Finally experiments will investigate the flow of information within areas of the prefrontal cortex and between the prefrontal cortex and other cortical areas. Collectively, these experiments will uncover the fundamental mechanisms through which the neural circuits of the prefrontal cortex allow the maintenance of visual object information in working memory.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $647,403 )
2025	2025	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Vision Research	000	14	1/13/2025	NON-COMPETING CONTINUATION	$647,403
														Subtotal = $647,403

Issue Date FY: 2024 ( Subtotal = $631,236 )
2024	2024	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Vision Research	002	13	1/11/2024	COMPETING CONTINUATION	$35,876
2024	2024	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Vision Research	001	13	12/13/2023	COMPETING CONTINUATION	$631,236
2024	2021	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Vision Research	000	12	12/5/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$35,876
														Subtotal = $631,236

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	001	11	4/24/2023	NON-COMPETING CONTINUATION	$161,406
2023	2021	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Vision Research	002	12	5/16/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$145,068
2023	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	000	10	3/13/2023	NON-COMPETING CONTINUATION	-$306,473
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Vision Research	003	12	6/14/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$168,178
2022	2021	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Vision Research	001	12	12/17/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2022	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	000	11	12/16/2021	NON-COMPETING CONTINUATION	$0
2022	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	002	10	6/14/2022	NON-COMPETING CONTINUATION	-$168,178
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $454,401 )
2021	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	000	11	5/26/2021	NON-COMPETING CONTINUATION	$454,400
2021	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	001	11	6/30/2021	NON-COMPETING CONTINUATION	-$454,400
2021	2021	VANDERBILT UNIVERSITY, THE	110 21ST AVENUE S STE 800	NASHVILLE	TN	37203	DAVIDSON	USA	Vision Research	003	12	8/11/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$454,401
2021	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	002	10	8/11/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $454,401

Issue Date FY: 2020 ( Subtotal = $468,392 )
2020	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	000	10	5/19/2020	NON-COMPETING CONTINUATION	$468,392
														Subtotal = $468,392

Issue Date FY: 2019 ( Subtotal = $492,453 )
2019	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	000	9	5/23/2019	COMPETING CONTINUATION	$492,453
														Subtotal = $492,453

Issue Date FY: 2017 ( Subtotal = -$9,990 )
2017	2015	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	000	8	6/26/2017	NON-COMPETING CONTINUATION	-$9,990
														Subtotal = -$9,990

Issue Date FY: 2015 ( Subtotal = $383,474 )
2015	2015	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	000	8	3/19/2015	NON-COMPETING CONTINUATION	$383,474
														Subtotal = $383,474

Issue Date FY: 2014 ( Subtotal = $391,300 )
2014	2014	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	000	7	3/21/2014	NON-COMPETING CONTINUATION	$358,974
2014	2014	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	001	7	3/27/2014	NON-COMPETING CONTINUATION	$32,326
														Subtotal = $391,300

Issue Date FY: 2013 ( Subtotal = $317,300 )
2013	2013	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	000	6	3/11/2013	NON-COMPETING CONTINUATION	$300,600
2013	2013	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	001	6	6/6/2013	NON-COMPETING CONTINUATION	$16,700
														Subtotal = $317,300

Issue Date FY: 2012 ( Subtotal = $396,029 )
2012	2012	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	000	5	3/20/2012	COMPETING CONTINUATION	$370,000
2012	2012	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	001	5	9/10/2012	SUPPLEMENT FOR EXPANSION	$26,029
														Subtotal = $396,029

Issue Date FY: 2009 ( Subtotal = $313,512 )
2009	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	001	4	4/27/2009	NON-COMPETING CONTINUATION	$31,351
2009	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	000	4	12/2/2008	NON-COMPETING CONTINUATION	$282,161
														Subtotal = $313,512

Issue Date FY: 2008 ( Subtotal = $307,242 )
2008	2008	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	000	3	12/10/2007	NON-COMPETING CONTINUATION	$307,242
														Subtotal = $307,242

Issue Date FY: 2007 ( Subtotal = $302,952 )
2007	2007	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	000	2	1/17/2007	NON-COMPETING CONTINUATION	$302,952
														Subtotal = $302,952

Issue Date FY: 2006 ( Subtotal = $312,000 )
2006	2006	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Vision Research	000	1	12/27/2005	NEW	$312,000
														Subtotal = $312,000

Grand Total All Awards = $5,407,704

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Neurophysiological Effects of Training in Visual Cognitive Tasks

Award Number: R01EY017077

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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