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Global Synpatic Plasticity Mechanisms in Visual Cortex

Award Number: R01EY014882
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2004
PERIOD OF PERFORMANCE END DATE: 01/31/2030

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Global Synpatic Plasticity Mechanisms in Visual Cortex - Project Summary The primary visual cortex (V1) does not work in isolation but is heavily influenced by other sensory and higher cognitive functions, which arrive through long-range intracortical and subcortical connections. Under normal conditions, these non-visual inputs provide context to visual processing and allow top-down control of visual learning. In the event of losing vision, these long-range inputs may undergo functional plasticity to recruit the deprived V1 for processing multisensory information. In contrast, in the absence of audition, it has been shown that there is compensatory plasticity in the visual areas to allow functional enhancement and refinement of visual processing, some of which may be mediated by plasticity within V1. Our prior work demonstrated that there is prominent neural circuit plasticity that occurs in the mouse V1 following adult-onset visual deprivation (VD) and auditory deprivation (AD). In particular, we found that adult-onset VD leads to potentiation of the lateral intracortical inputs to V1 layer 2/3 (L2/3) principal neurons without change in synapses serving the feedforward pathway that convey visual information. In contrast, we observed potentiation of the feedforward pathway, including recovery of thalamocortical (TC) long-term potentiation (LTP) in layer 4 (L4) of V1 following adult-onset AD. These results highlight the innate potential for plasticity in the adult V1, as well as indicate that the adult V1 adapts in a distinct manner dependent on the nature of sensory deprivation. Based on our previous findings, we hypothesize that adult-onset VD and AD may be leveraged to respectively promote the plasticity of top-down and feedforward circuits. In this application, we will determine the plasticity of circuits mediating cross-modal recruitment of V1 with adult-onset VD (Aim 1) and the functional changes in V1 following adult-onset AD that can promote and refine visual processing (Aim 2). Results from our study will provide in vivo functional consequences of circuit-level plasticity, as well as mechanistic information on how the adult V1 adapts to VD and AD. Such information can be utilized to develop effective means to selectively promote top-down contextual control over visual functions or enhance feedforward visual processing abilities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $500,038 )
2026	2026	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	002	21	4/7/2026	COMPETING CONTINUATION	$500,038
2026	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	001	20	4/2/2026	NON-COMPETING CONTINUATION	$0
2026	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	000	20	10/1/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $500,038

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	000	20	7/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $409,375 )
2024	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	000	20	8/28/2024	NON-COMPETING CONTINUATION	$409,375
														Subtotal = $409,375

Issue Date FY: 2023 ( Subtotal = $409,375 )
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	002	19	8/15/2023	NON-COMPETING CONTINUATION	$409,375
2023	2022	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	001	18	7/2/2023	COMPETING CONTINUATION	$0
2023	2020	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	000	17	7/2/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $409,375

Issue Date FY: 2022 ( Subtotal = $409,375 )
2022	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	000	18	9/16/2022	COMPETING CONTINUATION	$409,375
														Subtotal = $409,375

Issue Date FY: 2020 ( Subtotal = $362,010 )
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	000	17	8/6/2020	NON-COMPETING CONTINUATION	$362,010
														Subtotal = $362,010

Issue Date FY: 2019 ( Subtotal = $362,010 )
2019	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	000	16	8/12/2019	NON-COMPETING CONTINUATION	$362,010
														Subtotal = $362,010

Issue Date FY: 2018 ( Subtotal = $362,010 )
2018	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	000	15	8/23/2018	NON-COMPETING CONTINUATION	$362,010
														Subtotal = $362,010

Issue Date FY: 2017 ( Subtotal = $399,993 )
2017	2017	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	002	14	8/23/2017	NON-COMPETING CONTINUATION	$361,563
2017	2017	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	003	14	9/6/2017	SUPPLEMENT FOR EXPANSION	$38,430
2017	2016	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	001	13	1/13/2017	COMPETING CONTINUATION	$47,541
2017	2015	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	000	12	1/13/2017	NON-COMPETING CONTINUATION	-$47,541
														Subtotal = $399,993

Issue Date FY: 2016 ( Subtotal = $360,577 )
2016	2016	JOHNS HOPKINS UNIVERSITY	1101 E 33RD STREET, STE-C-210	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	000	13	7/28/2016	COMPETING CONTINUATION	$360,577
														Subtotal = $360,577

Issue Date FY: 2015 ( Subtotal = $396,900 )
2015	2015	JOHNS HOPKINS UNIVERSITY	1101 E 33RD STREET, STE-C-210	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	000	12	8/26/2015	NON-COMPETING CONTINUATION	$396,900
														Subtotal = $396,900

Issue Date FY: 2014 ( Subtotal = $396,900 )
2014	2014	JOHNS HOPKINS UNIVERSITY	1101 E 33RD STREET, STE-C-210	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	000	11	8/26/2014	NON-COMPETING CONTINUATION	$396,900
														Subtotal = $396,900

Issue Date FY: 2013 ( Subtotal = $384,750 )
2013	2013	JOHNS HOPKINS UNIVERSITY	1101 E 33RD STREET, STE-C-210	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	000	10	8/19/2013	NON-COMPETING CONTINUATION	$384,750
														Subtotal = $384,750

Issue Date FY: 2012 ( Subtotal = $405,000 )
2012	2012	JOHNS HOPKINS UNIVERSITY	1101 E 33RD STREET, STE-C-210	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	000	9	8/31/2012	NON-COMPETING CONTINUATION	$405,000
														Subtotal = $405,000

Issue Date FY: 2011 ( Subtotal = $405,000 )
2011	2011	JOHNS HOPKINS UNIVERSITY	1101 E 33RD STREET, STE-C-210	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Vision Research	000	8	9/23/2011	COMPETING CONTINUATION	$405,000
														Subtotal = $405,000

Issue Date FY: 2010 ( Subtotal = $366,592 )
2010	2010	UNIVERSITY OF MARYLAND	4101 CHESAPEAKE BLDG	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Vision Research	000	7	8/18/2010	NON-COMPETING CONTINUATION	$366,592
														Subtotal = $366,592

Issue Date FY: 2009 ( Subtotal = $415,663 )
2009	2009	UNIVERSITY OF MARYLAND	4101 CHESAPEAKE BLDG	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Vision Research	000	5	6/19/2009	SUPPLEMENT FOR EXPANSION	$45,060
2009	2009	UNIVERSITY OF MARYLAND	4101 CHESAPEAKE BLDG	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Vision Research	001	6	8/25/2009	NON-COMPETING CONTINUATION	$370,603
														Subtotal = $415,663

Issue Date FY: 2008 ( Subtotal = $370,890 )
2008	2008	UNIVERSITY OF MARYLAND	4101 CHESAPEAKE BLDG	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Vision Research	000	5	9/15/2008	COMPETING CONTINUATION	$370,890
														Subtotal = $370,890

Issue Date FY: 2007 ( Subtotal = $288,396 )
2007	2007	UNIVERSITY OF MARYLAND	4101 CHESAPEAKE BLDG	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Vision Research	000	4	3/16/2007	NON-COMPETING CONTINUATION	$288,396
														Subtotal = $288,396

Issue Date FY: 2006 ( Subtotal = $290,021 )
2006	2006	UNIVERSITY OF MARYLAND	4101 CHESAPEAKE BLDG	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Vision Research	000	3	4/12/2006	NON-COMPETING CONTINUATION	$290,021
														Subtotal = $290,021

Issue Date FY: 2005 ( Subtotal = $297,000 )
2005	2005	UNIVERSITY OF MARYLAND	1410 SERVICE BUILDING	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Vision Research	000	2	3/24/2005	NON-COMPETING CONTINUATION	$297,000
														Subtotal = $297,000

Grand Total All Awards = $7,938,875

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Global Synpatic Plasticity Mechanisms in Visual Cortex

Award Number: R01EY014882

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2004

PERIOD OF PERFORMANCE END DATE: 01/31/2030

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