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Adaptation and visual coding

Award Number: R01EY010834
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/1994
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Adaptation and visual coding - Project summary Vision is a highly dynamic system that continuously adapts to changes in the stimulus properties of the environment or the physiological properties of the observer. How these adaptation processes adjust to the sensitivity limits of the observer is important for understanding normal visual function and the consequences of visual deficits or disease. The proposed research examines basic mechanisms of adaptation and plasticity by examining how color vision adjusts to losses in color sensitivity as a result of inherited color deficiencies. Color- deficient observers with anomalous trichromacy have weaker sensitivity to reddish-greenish colors because of alterations in the genes coding the medium and longwave photopigments. However, there is emerging evidence that the perceptual experience of color in anomalous trichromats is stronger than their sensitivity losses predict, potentially because the neural mechanisms encoding color amplify and thus compensate for the reduced color signals available from their receptors. Color deficiencies provide an ideal model for exploring these compensatory mechanisms, by comparing observers who differ because of well-defined and highly stable properties of the initial receptors, for which they have had a lifetime to adapt. The proposed studies are designed to assess the extent and mechanisms of these compensatory adjustments and how they are manifest in and impact different aspects of color perception. The first aim will compare color perception and contrast coding in normal and color-deficient observers across a battery of tasks designed to isolate different levels and properties of color vision. The second aim will complement these behavioral assessments with direct measures of cortical neural activity in normal and color-anomalous observers using functional magnetic resonance imaging, electroencephalography, and adaptive optics to probe neural responses to color. The results of these studies will serve to better characterize the neural and perceptual consequences of color deficiencies, and more generally will characterize basic processes underlying human vision and how it adapts in response to visual losses or their corrections.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER ED	1664 N VIRGINIA ST # 285	RENO	NV	89557	WASHOE	USA	Vision Research	000	22	4/10/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $356,726 )
2023	2023	NEVADA SYSTEM OF HIGHER EDUCATION	1664 N VIRGINIA ST	RENO	NV	89557	WASHOE	USA	Vision Research	000	22	6/9/2023	NON-COMPETING CONTINUATION	$356,726
														Subtotal = $356,726

Issue Date FY: 2022 ( Subtotal = $346,025 )
2022	2022	NEVADA SYSTEM OF HIGHER EDUCATION	1664 N VIRGINIA ST	RENO	NV	89557	WASHOE	USA	Vision Research	000	21	4/28/2022	NON-COMPETING CONTINUATION	$346,025
2022	2022	NEVADA SYSTEM OF HIGHER EDUCATION	1664 N VIRGINIA ST	RENO	NV	89557	WASHOE	USA	Vision Research	001	21	8/10/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $346,025

Issue Date FY: 2021 ( Subtotal = $346,024 )
2021	2021	NEVADA SYSTEM OF HIGHER EDUCATION	1664 N VIRGINIA ST	RENO	NV	89557	WASHOE	USA	Vision Research	000	20	4/29/2021	NON-COMPETING CONTINUATION	$346,024
														Subtotal = $346,024

Issue Date FY: 2020 ( Subtotal = $356,726 )
2020	2020	NEVADA SYSTEM OF HIGHER EDUCATION	1664 N VIRGINIA ST	RENO	NV	89557	WASHOE	USA	Vision Research	000	19	4/17/2020	NON-COMPETING CONTINUATION	$356,726
														Subtotal = $356,726

Issue Date FY: 2019 ( Subtotal = $356,726 )
2019	2019	NEVADA SYSTEM OF HIGHER EDUCATION	1664 N VIRGINIA ST	RENO	NV	89557	WASHOE	USA	Vision Research	000	18	4/11/2019	COMPETING CONTINUATION	$356,726
														Subtotal = $356,726

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2015	NEVADA SYSTEM OF HIGHER EDUCATION	1664 N VIRGINIA ST	RENO	NV	89557	WASHOE	USA	Vision Research	000	17	10/19/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $278,402 )
2015	2015	UNIVERSITY OF NEVADA-RENO	**	RENO	NV	89557	WASHOE	USA	Vision Research	000	17	7/27/2015	NON-COMPETING CONTINUATION	$278,402
														Subtotal = $278,402

Issue Date FY: 2014 ( Subtotal = $278,402 )
2014	2014	UNIVERSITY OF NEVADA-RENO	**	RENO	NV	89557	WASHOE	USA	Vision Research	000	16	7/28/2014	NON-COMPETING CONTINUATION	$278,402
														Subtotal = $278,402

Issue Date FY: 2013 ( Subtotal = $275,601 )
2013	2013	UNIVERSITY OF NEVADA-RENO	204 Ross Hall Mailstop 325	RENO	NV	89557	WASHOE	USA	Vision Research	000	15	7/16/2013	COMPETING CONTINUATION	$275,601
														Subtotal = $275,601

Issue Date FY: 2010 ( Subtotal = $242,544 )
2010	2010	UNIVERSITY OF NEVADA-RENO	204 Ross Hall Mailstop 325	RENO	NV	89557	WASHOE	USA	Vision Research	000	14	4/28/2010	NON-COMPETING CONTINUATION	$242,544
														Subtotal = $242,544

Issue Date FY: 2009 ( Subtotal = $244,993 )
2009	2009	UNIVERSITY OF NEVADA-RENO	204 Ross Hall Mailstop 325	RENO	NV	89557	WASHOE	USA	Vision Research	000	13	3/26/2009	NON-COMPETING CONTINUATION	$244,993
														Subtotal = $244,993

Issue Date FY: 2008 ( Subtotal = $240,094 )
2008	2008	UNIVERSITY OF NEVADA-RENO	**	RENO	NV	89557	WASHOE	USA	Vision Research	000	12	3/13/2008	NON-COMPETING CONTINUATION	$240,094
														Subtotal = $240,094

Issue Date FY: 2007 ( Subtotal = $244,993 )
2007	2007	UNIVERSITY OF NEVADA-RENO	**	RENO	NV	89557	WASHOE	USA	Vision Research	000	11	3/15/2007	NON-COMPETING CONTINUATION	$244,993
														Subtotal = $244,993

Issue Date FY: 2006 ( Subtotal = $250,060 )
2006	2006	UNIVERSITY OF NEVADA-RENO	**	RENO	NV	89557	WASHOE	USA	Vision Research	000	10	3/13/2006	COMPETING CONTINUATION	$250,060
														Subtotal = $250,060

Issue Date FY: 2003 ( Subtotal = $202,322 )
2003	2003	UNIVERSITY OF NEVADA-RENO	**	RENO	NV	89557	WASHOE	USA	Vision Research	000	9	7/17/2003	NON-COMPETING CONTINUATION	$202,322
														Subtotal = $202,322

Issue Date FY: 2002 ( Subtotal = $201,682 )
2002	2002	UNIVERSITY OF NEVADA-RENO	**	RENO	NV	89557	WASHOE	USA	Vision Research	001	8	9/2/2002	SUPPLEMENT FOR EXPANSION	$21,307
2002	2002	UNIVERSITY OF NEVADA-RENO	**	RENO	NV	89557	WASHOE	USA	Vision Research	000	8	8/16/2002	NON-COMPETING CONTINUATION	$180,375
														Subtotal = $201,682

Issue Date FY: 2001 ( Subtotal = $180,375 )
2001	2001	UNIVERSITY OF NEVADA-RENO	**	RENO	NV	89557	WASHOE	USA	Vision Research	000	7	7/26/2001	NON-COMPETING CONTINUATION	$180,375
														Subtotal = $180,375

Issue Date FY: 2000 ( Subtotal = $173,730 )
2000	2000	UNIVERSITY OF NEVADA-RENO	**	RENO	NV	89557	WASHOE	USA	Vision Research	000	6	8/24/2000	COMPETING CONTINUATION	$173,730
														Subtotal = $173,730

Grand Total All Awards = $4,575,425

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Adaptation and visual coding

Award Number: R01EY010834

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/1994

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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