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Functional connectivity in primary visual cortex

Award Number: R01EY005253
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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PROJECT SUMMARY All animals that can form images in their retinas, from flies to humans, need ON and OFF brain pathways to process light and dark features in visual scenes. The traditional textbook view is that these ON and OFF pathways fully converge in visual cortex to make neurons selective to stimulus orientation but invariant to stimulus polarity and spatial phase. Against this traditional view, our recent work demonstrates that ON and OFF pathways segregate in visual cortex, specialize in different spatiotemporal functions, and process images relatively independently from each other. In addition, our preliminary results indicate that ON and OFF cortical pathways respond very differently to changes in luminance range, which varies continuously in our visual environment from sunrise to sunset. Based on our results, we hypothesize that luminance perception originates from the interaction between two separate and relatively independent ON and OFF pathways that are exquisitely matched to the statistics of light and dark features in natural scenes. This new understanding of ON and OFF cortical processing has important implications for human luminance perception, image brain processing analysis and could help improve the diagnostic tools available to manage treatment in human visual disease. In this proposal, we will investigate how ON and OFF cortical pathways interact to generate luminance perception, and how these interactions vary with background luminance, luminance range and the rod/cone retinal ratio available to sample the images. We will then use all these measurements to develop models that replicate human luminance perception more accurately than in the past and new diagnostic tools that measure human ON and OFF visual function in diseases that affect the retina (e.g. glaucoma) and visual cortex (e.g. amblyopia).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $405,000 )
2023	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	000	37	7/12/2023	NON-COMPETING CONTINUATION	$405,000
														Subtotal = $405,000

Issue Date FY: 2022 ( Subtotal = $392,850 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	000	36	7/5/2022	NON-COMPETING CONTINUATION	$392,850
														Subtotal = $392,850

Issue Date FY: 2021 ( Subtotal = $392,850 )
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	002	35	8/5/2021	NON-COMPETING CONTINUATION	$392,850
2021	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	001	34	6/17/2021	COMPETING CONTINUATION	$157,623
2021	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	000	33	6/17/2021	NON-COMPETING CONTINUATION	-$157,623
														Subtotal = $392,850

Issue Date FY: 2020 ( Subtotal = $405,000 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	001	34	8/6/2020	COMPETING CONTINUATION	$405,000
2020	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	000	33	7/31/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $405,000

Issue Date FY: 2019 ( Subtotal = $405,000 )
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	000	33	6/21/2019	NON-COMPETING CONTINUATION	$405,000
														Subtotal = $405,000

Issue Date FY: 2018 ( Subtotal = $405,000 )
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	002	32	6/29/2018	NON-COMPETING CONTINUATION	$405,000
2018	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	001	31	2/8/2018	COMPETING CONTINUATION	$4,292
2018	2016	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	000	30	2/8/2018	EXTENSION WITH OR WITHOUT FUNDS	-$4,292
														Subtotal = $405,000

Issue Date FY: 2017 ( Subtotal = $405,000 )
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	003	31	9/7/2017	COMPETING CONTINUATION	$405,000
2017	2016	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	002	30	9/4/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
2017	2016	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	001	30	1/31/2017	EXTENSION WITH OR WITHOUT FUNDS	$178,963
2017	2015	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	33 W 42ND STREET FL 19	NEW YORK	NY	10036	NEW YORK	USA	Vision Research	000	29	1/31/2017	NON-COMPETING CONTINUATION	-$178,963
														Subtotal = $405,000

Issue Date FY: 2016 ( Subtotal = $269,250 )
2016	2016	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Vision Research	000	30	7/11/2016	EXTENSION WITH OR WITHOUT FUNDS	$269,250
														Subtotal = $269,250

Issue Date FY: 2015 ( Subtotal = $263,865 )
2015	2015	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Vision Research	001	29	8/17/2015	NON-COMPETING CONTINUATION	$134,449
2015	2015	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Vision Research	000	29	7/20/2015	NON-COMPETING CONTINUATION	$129,416
														Subtotal = $263,865

Issue Date FY: 2014 ( Subtotal = $263,865 )
2014	2014	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Vision Research	000	28	7/17/2014	NON-COMPETING CONTINUATION	$263,865
														Subtotal = $263,865

Issue Date FY: 2013 ( Subtotal = $255,788 )
2013	2013	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Vision Research	000	27	8/19/2013	NON-COMPETING CONTINUATION	$255,788
														Subtotal = $255,788

Issue Date FY: 2012 ( Subtotal = $395,850 )
2012	2012	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Vision Research	001	26	8/14/2012	COMPETING CONTINUATION	$269,250
2012	2012	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Vision Research	002	26	9/17/2012	SUPPLEMENT FOR EXPANSION	$126,600
2012	2011	SUNY, COLLEGE OF OPTOMETRY	122 EAST 25TH STREET	NEW YORK-NEW YORK	NY	10010		USA	Vision Research	000	25	8/10/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $395,850

Issue Date FY: 2011 ( Subtotal = $315,604 )
2011	2011	SUNY, COLLEGE OF OPTOMETRY	122 EAST 25TH STREET	NEW YORK-NEW YORK	NY	10010		USA	Vision Research	001	25	5/18/2011	NON-COMPETING CONTINUATION	$19,725
2011	2011	SUNY, COLLEGE OF OPTOMETRY	122 EAST 25TH STREET	NEW YORK-NEW YORK	NY	10010		USA	Vision Research	000	25	3/23/2011	NON-COMPETING CONTINUATION	$295,879
														Subtotal = $315,604

Issue Date FY: 2010 ( Subtotal = $328,754 )
2010	2010	SUNY, COLLEGE OF OPTOMETRY	33 W 42nd St	New York	NY	10036	NEW YORK	USA	Vision Research	000	24	4/22/2010	NON-COMPETING CONTINUATION	$328,754
														Subtotal = $328,754

Issue Date FY: 2009 ( Subtotal = $332,075 )
2009	2009	SUNY, COLLEGE OF OPTOMETRY	33 W 42nd St	New York	NY	10036	NEW YORK	USA	Vision Research	000	23	3/26/2009	NON-COMPETING CONTINUATION	$332,075
														Subtotal = $332,075

Issue Date FY: 2008 ( Subtotal = $325,434 )
2008	2008	SUNY, COLLEGE OF OPTOMETRY	122 EAST 25TH STREET	NEW YORK-NEW YORK	NY	10010		USA	Vision Research	000	22	3/13/2008	NON-COMPETING CONTINUATION	$325,434
														Subtotal = $325,434

Issue Date FY: 2007 ( Subtotal = $421,825 )
2007	2007	SUNY, COLLEGE OF OPTOMETRY	122 EAST 25TH STREET	NEW YORK-NEW YORK	NY	10010		USA	Vision Research	000	21	3/26/2007	COMPETING CONTINUATION	$421,825
														Subtotal = $421,825

Issue Date FY: 2004 ( Subtotal = $360,812 )
2004	2004	SUNY, COLLEGE OF OPTOMETRY	122 EAST 25TH STREET	NEW YORK-NEW YORK	NY	10010		USA	Vision Research	000	20	8/12/2004	NON-COMPETING CONTINUATION	$360,812
														Subtotal = $360,812

Issue Date FY: 2003 ( Subtotal = $346,582 )
2003	2003	SUNY, COLLEGE OF OPTOMETRY	122 EAST 25TH STREET	NEW YORK-NEW YORK	NY	10010		USA	Vision Research	000	19	8/29/2003	NON-COMPETING CONTINUATION	$346,582
														Subtotal = $346,582

Grand Total All Awards = $7,779,444

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Functional connectivity in primary visual cortex

Award Number: R01EY005253

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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