Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Evaluation and Comparison of Impacts of Flavored Waterpipe Tobacco and Electronic Waterpipe E-Liquid Formulation Variations on Toxicant Yields and Particle Size Distribution in Mainstream Emissions

Award Number: R01ES033016
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/18/2021
PERIOD OF PERFORMANCE END DATE: 05/31/2024

Group Awards By:

View Award Description

Evaluation and Comparison of Impacts of Flavored Waterpipe Tobacco and Electronic Waterpipe E-Liquid Formulation Variations on Toxicant Yields and Particle Size Distribution in Mainstream Emissions - Project Summary Waterpipe (WP) smoking has become a popular form of tobacco use in the US, especially among youth and young adults. These groups are particularly attracted to flavored WP tobacco (WPT). Sweet WPT flavors are preferred, with fruit flavors in particular leading to initiation and continued WP use, as well as the misperception of WP smoking as less harmful than cigarette smoking. WPT smoking has been linked to many of the same adverse health effects as cigarette smoking and releases many of the same harmful and potentially harmful constituents (HPHCs) as cigarettes, at 10-100 times increased levels. The popularity of flavored WP smoking has expanded in recent years to flavored tobacco-free alternatives, including electronic WP (EWP). EWP replaces the traditional WP bowl and heat source with an electronic head filled with flavored, nicotine-containing liquid (e-liquid), turning the WP into an electronic nicotine delivery system (ENDS). Given the rising popularity of other flavored ENDS, EWP may pose similar appeal and uptake concerns. EWP may be perceived as a safe WP alternative, but it has the potential to release the same harmful emissions as other ENDS. Yet nothing is known about the safety of EWP, or if it offers any harm reductions compared to WPT smoking. Flavored WP products may play an important role in the direct harms of WP smoking. EWP e-liquids and WPTs both use flavorants, sweet humectants (propylene glycol and glycerol), and sugars to enhance their appeal. These ingredients in cigarettes have been shown to form toxic aldehydes and furans during smoking. ENDS research shows that variations in e-liquid humectant content, as well as the presence of flavorings, can increase aldehydes emissions. Fundamental knowledge is lacking on the range of toxicants emissions across flavored WP products and the impact of variations in product formulations on toxic emissions and particle size distribution, a critical parameter in the delivery of toxicants to the human respiratory system. In order to regulate WP smoking and set product standards to reduce harms and public health impacts, it is imperative that US Food and Drug Administration have data to understand the impact of flavored WP smoking on exposure and how exposures may differ between traditional and alternative WP smoking platforms. This study will fill these gaps by evaluating and comparing the impact of variations in flavor profiles, humectants and sugar levels, and heating temperatures, in a variety of commercially available WPTs and EWP e-liquids on yields of HPHCs and other toxicants as well as particle size distribution in mainstream WP emissions. This will also be the first study to measure toxicant emissions from EWP use. This study is an essential step in providing robust, fundamental information on WP product formulations and toxicant emissions to better understand relative harms associated with flavored WP smoking and establish a knowledge base to inform regulatory actions surrounding WP product standards.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$9,906 )
2025	2023	BATTELLE MEMORIAL INSTITUTE	505 KING AVE	COLUMBUS	OH	43201	FRANKLIN	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	3	12/19/2024	NON-COMPETING CONTINUATION	-$9,906
														Subtotal = -$9,906

Issue Date FY: 2023 ( Subtotal = $454,372 )
2023	2023	BATTELLE MEMORIAL INSTITUTE	505 KING AVE	COLUMBUS	OH	43201	FRANKLIN	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	001	3	5/25/2023	NON-COMPETING CONTINUATION	$454,372
2023	2022	BATTELLE MEMORIAL INSTITUTE	505 KING AVE	COLUMBUS	OH	43201	FRANKLIN	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	2	3/7/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $454,372

Issue Date FY: 2022 ( Subtotal = $454,029 )
2022	2022	BATTELLE MEMORIAL INSTITUTE	505 KING AVE	COLUMBUS	OH	43201	FRANKLIN	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	002	2	5/26/2022	NON-COMPETING CONTINUATION	$454,029
2022	2021	BATTELLE MEMORIAL INSTITUTE	505 KING AVE	COLUMBUS	OH	43201	FRANKLIN	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	001	1	4/28/2022	NEW	$0
2022	2021	BATTELLE MEMORIAL INSTITUTE	505 KING AVE	COLUMBUS	OH	43201	FRANKLIN	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	1	11/30/2021	NEW	$0
														Subtotal = $454,029

Issue Date FY: 2021 ( Subtotal = $454,400 )
2021	2021	BATTELLE MEMORIAL INSTITUTE	505 KING AVE	COLUMBUS	OH	43201	FRANKLIN	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	1	8/17/2021	NEW	$454,400
														Subtotal = $454,400

Grand Total All Awards = $1,352,895

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Evaluation and Comparison of Impacts of Flavored Waterpipe Tobacco and Electronic Waterpipe E-Liquid Formulation Variations on Toxicant Yields and Particle Size Distribution in Mainstream Emissions

Award Number: R01ES033016

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/18/2021

PERIOD OF PERFORMANCE END DATE: 05/31/2024

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer