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Optimization of milli-spinner thrombectomy for enhanced clot debulking efficiency and safety

Award Number: R01EB039955
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/05/2026
PERIOD OF PERFORMANCE END DATE: 08/04/2030

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Optimization of milli-spinner thrombectomy for enhanced clot debulking efficiency and safety - Significance. Acute Ischemic Stroke (AIS) is the leading cause of disability and the flfth leading cause of death in the U.S., resulting from blocked or interrupted blood Ʋow in cervical or cerebral arteries. Current thrombectomy devices (aspiration and stent-retrievers) have transformed AIS treatment, but fail in ~15% of patients due to resistant clots and achieve the flrst-pass effect in fewer than 50% of cases. Patients requiring multiple passes face longer procedure times, higher complication risks, and worse functional outcomes. A transformative thrombectomy strategy is urgently needed to address these limitations and improve clinical success rates. Innovation. We recently developed an innovative milli-spinner thrombectomy technology that employs controlled microstructure densiflcation to shrink and debulk clots, enabling faster and more complete removal. Preliminary in-vivo studies demonstrate superior outcomes compared to aspiration devices, underscoring the potential to redeflne the flrst-pass effect benchmark. This technology introduces a new class of clot-removal mechanisms based on dynamic microstructural remodeling, rather than bulk aspiration or retrieval alone. By integrating multi-scale modeling, surrogate optimization, and animal validation, our proposal establishes the flrst systematic, mechanism-driven framework for device-level understanding and translation of spinner-based thrombectomy. Approach. We propose three aims: 1. Mechanistic Studies: Perform in-vitro experiments and computational simulations to quantify clot microstructure response under spinner-induced mechanical loading. 2. Optimization: Develop a surrogate-model-guided framework that integrates experimental and simulation data to optimize spinner design and operating parameters for efficiency and safety. 3. Validation: Conduct in-vivo validation in animal models to conflrm optimized performance, impose physiologic constraints, and mitigate procedural risks. Impact. This research will deliver the flrst comprehensive platform for mechanism-driven optimization of milli-spinner thrombectomy. Our goal is to increase the flrst-pass effect from <50% with current devices to >80% with optimized spinners. Achieving this target would represent a step-change in AIS treatment, reducing procedure time, minimizing complications, and substantially improving patient outcomes. By providing mechanistic insights, validated models, and optimized designs, this work will advance milli- spinner thrombectomy into a transformative class of devices capable of treating clots that currently defeat existing therapies, with broad implications for endovascular medicine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,421,019 )
2026	2026	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	8/3/2026	NEW	$637,196
2026	2026	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	8/11/2026	NEW	$1,783,823
														Subtotal = $2,421,019

Grand Total All Awards = $2,421,019

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Optimization of milli-spinner thrombectomy for enhanced clot debulking efficiency and safety

Award Number: R01EB039955

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/05/2026

PERIOD OF PERFORMANCE END DATE: 08/04/2030

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