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UniBrain: An End-to-End Unified Toolkit for Comprehensive Neuroimaging Analysis

Award Number: R01EB038426
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/03/2026
PERIOD OF PERFORMANCE END DATE: 07/31/2030

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UniBrain: An End-to-End Unified Toolkit for Comprehensive Neuroimaging Analysis - Project Summary Overview: This project aims to revolutionize current methodologies by establishing an integrated, end-to-end deep learning architecture, UniBrain, that streamlines and optimizes the entire brain image processing pipeline. The overarching goals of UniBrain are to address critical gaps in brain imaging processes by: (G1) developing a flexible and robust AI-driven tool for diverse imaging modalities, (G2) enhancing interpretability and streamlining workflow integration to facilitate seamless adoption in clinical settings, and (G3) conducting extensive validation of the toolkit’s effectiveness across various clinical datasets to ensure its reliability and applicability in real-world scenarios. The Specific Aims include: Aim 1: Develop a Unified End-to-End Framework for Raw Structural Imaging-to-Graph Transformation: We will develop a unified end-to-end deep learning architecture to precisely generate brain graphs from raw struc- tural imaging data, ensuring seamless integration across preprocessing stages. By streamlining data transforma- tion processes in an end-to-end manner, this approach will ensure consistency and accuracy in data preparation, provide a solid foundation for subsequent analyses, and enhance the depth and significance of the results. Aim 2: Establish a Holistic End-to-End Framework for Raw Functional Imaging-to-Graph Transformation: We will develop a holistic end-to-end framework to transform raw functional imaging data into both static and dynamic graphs through unified algorithm design. This approach will enable us to capture the brain’s functional connections more effectively, thereby enhancing our understanding of brain dynamics. Aim 3: Create an Integrated Framework for Raw Imaging-to-Graph Based Multimodal Brain Graph Min- ing: We will develop an end-to-end multimodal framework to process structural and functional imaging data simultaneously, producing integrated brain graph representations that capture complex brain architectures and their multimodal interactions. Aim 4: Validate the Reproducibility of Imaging Biomarkers and Clinical Findings Across Diverse Settings: We will systematically validate the robustness of UniBrain’s methodologies by replicating imaging biomarkers and clinical findings across diverse experimental and clinical datasets. This will ensure the reproducibility and reliability of observed results, demonstrating that the toolkit can generate consistent and clinically meaningful outcomes in varied settings. The successful completion of this project will fundamentally transform brain imaging analysis through advanced AI integration. By enhancing the processing, modeling, and interpretation of brain imaging data, UniBrain intro- duces a streamlined “one-click, done-quick” protocol, empowering the research community with unprecedented efficiency. This initiative is poised to drive breakthroughs in understanding brain function, development, aging, and disease while opening new frontiers in medical practice and research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $818,259 )
2026	2026	LEHIGH UNIVERSITY	526 BRODHEAD AVE	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/4/2026	NEW	$818,259
														Subtotal = $818,259

Grand Total All Awards = $818,259

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UniBrain: An End-to-End Unified Toolkit for Comprehensive Neuroimaging Analysis

Award Number: R01EB038426

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/03/2026

PERIOD OF PERFORMANCE END DATE: 07/31/2030

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