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Coherence engineering of a human brain interferometer to quantitatively and specifically measure cerebral blood flow

Award Number: R01EB035762
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/11/2024
PERIOD OF PERFORMANCE END DATE: 11/30/2028

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Coherence engineering of a human brain interferometer to quantitatively and specifically measure cerebral blood flow - Abstract: Occurring after subarachnoid hemorrhage (SAH), delayed cerebral ischemia (DCI) is a major cause of morbidity and mortality. In aneurysmal SAH, DCI occurs in up to 30-50% of survivors. The consequences of DCI are severe, in part because it is often detected too late by conventional monitoring and imaging protocols, preventing timely intervention. Near-infrared (NIR) optical monitoring of relative cerebral blood flow (CBF) after SAH has been performed by diffuse correlation spectroscopy (DCS). DCS has shown the potential of optical CBF measurements, but remains limited to sampling the forehead with marginal brain specificity. Quantitative CBF measurements are further hampered by superficial tissue contamination. Our group recently advanced a new approach called interferometric diffuse optics (iDO). In separate implementations, this new approach has provided highly parallel detection (~300x more channels than conventional single channel DCS detection) and time-of-flight (TOF) information. Here we propose to further enhance and unify these advantages in a single implementation (detection scheme) that improves the measurement signal-to-noise ratio by 100x and channel number by 1000x relative to single channel DCS, while also providing time-of-flight information. This unique approach will improve the SNR of the autocorrelation, from which optical CBF is derived, by ten million-fold compared to DCS (if all channels are pooled). The same system will also provide time-of-flight information to account for variability in head geometry and superficial blood flow and provide quantitative optical CBF that can be compared across time, locations, and subjects. In this proposal, we will develop a 1064 nm iDO system that uses the new concept of coherence engineering to provide TOF information and reduce S-C separation, thus improving photon counts (Aim 1). We will benchmark this new system against existing technologies in our laboratory and validate its capabilities (Aim 2). Finally, we will deploy an iDO instrument in the neuro-intensive care unit (ICU) for observational monitoring of SAH patients across the head and test whether optical CBF can diagnose DCI (Aim 3). Beyond DCI, the interferometric technology delivered here can be applied in ischemic stroke, traumatic brain injury, and other neurological disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $510,644 )
2026	2026	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	12/17/2025	NON-COMPETING CONTINUATION	$510,644
														Subtotal = $510,644

Issue Date FY: 2025 ( Subtotal = $663,606 )
2025	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	7/4/2025	NEW	$82,952
2025	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	12/11/2024	NEW	$580,654
														Subtotal = $663,606

Grand Total All Awards = $1,174,250

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Coherence engineering of a human brain interferometer to quantitatively and specifically measure cerebral blood flow

Award Number: R01EB035762

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/11/2024

PERIOD OF PERFORMANCE END DATE: 11/30/2028

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