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A direct-indirect dual-layer flat-panel detector for breast cancer detection

Award Number: R01EB035551
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2024
PERIOD OF PERFORMANCE END DATE: 02/29/2028

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A direct-indirect dual-layer flat-panel detector for breast cancer detection - Project Abstract The goal of the proposed work is to develop a novel dual-layer flat-panel detector (DLFPD) based on mature energy-integrating detector technology and translate it clinically for dual- energy spectral digital breast tomosynthesis (DE-DBT). This will improve the outcome of breast cancer screening, diagnosis and treatment monitoring. Our objectives are two folds: 1. Develop a DLFPD to allow rapid clinical translation of spectral breast imaging without patient motion artifact. 2. Develop spectral imaging techniques based on DLFPD and establish its clinical feasibility using patient studies. Our objectives will be accomplished through the following three specific aims: (1) Design, optimize and fabricate a prototype DLFPD for spectral breast imaging. Aim 1 will lead to the development and clinical translation of DLFPD that acquires two mammograms at different energies using a single exposure, allowing perfectly registered spectral images without artifacts due to patient motion. (2) Develop DLFPD based DE-DBT techniques using simulation methods. Aim 2 will lead to the development of spectral image processing techniques for DLFPD based systems with and without iodinated contrast agent. (3) Integrate the prototype DLFPD with a clinical DBT system and investigate DE-DBT performance through phantom and patient imaging studies. Aim 3 will translate the DLFPD and DE-DBT techniques developed in Aims 1 and 2 into clinical reality. The outcomes of the proposed work are: 1. Advancement in DLFPD hardware that permit rapid clinical translation; 2. Development of a variety of DLFPD based DE-DBT techniques, with and without iodinated contrast agent; 3. Clinical evaluation of the feasibility of DE-DBT for breast cancer detection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $553,492 )
2026	2026	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	4/1/2026	NON-COMPETING CONTINUATION	$553,492
														Subtotal = $553,492

Issue Date FY: 2025 ( Subtotal = $500,622 )
2025	2025	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	3/25/2025	NON-COMPETING CONTINUATION	$500,622
														Subtotal = $500,622

Issue Date FY: 2024 ( Subtotal = $572,103 )
2024	2024	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	5/20/2024	NEW	$572,103
														Subtotal = $572,103

Grand Total All Awards = $1,626,217

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A direct-indirect dual-layer flat-panel detector for breast cancer detection

Award Number: R01EB035551

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2024

PERIOD OF PERFORMANCE END DATE: 02/29/2028

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