Thursday, December 18, 2025 12/18/2025

Engineering pluripotent stem cells to evade and promote immunity

Award Number: R01EB035491
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/15/2023
PERIOD OF PERFORMANCE END DATE: 11/30/2027

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Engineering pluripotent stem cells to evade and promote immunity - PROJECT SUMMARY / ABSTRACT Pluripotent stem cells hold great promise for regenerative medicine. Beyond their ability to restore normal tissues, their potential can be expanded even further through engineering approaches to create new lineages with therapeutic properties that are not normally made in vivo. In preliminary studies, we have created pluripotent stem cell lines that 1) have been genomically edited such that they are able to cross human-mouse barriers; 2) engineered these cells to carry a knockin insertion of a broadly neutralizing HIV antibody at the endogenous loci. With these cells, we will develop strategies to differentiate human pluripotent stem cells into transplantable pathogen-specific plasma cells. This process will involve iterative and recursive steps to engineer pluripotent stem cell differentiation to downstream hematopoietic, B cell, and plasma cell lineages using single cell transcriptional trajectories as guides. These targeted approaches will be complemented with unbiased genetic and small molecule screens for new pathways that promote or inhibit specific steps in differentiation, and additional single cell transcriptomic and epigenetic analyses to provide templates for cellular engineering.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $477,398 )
2026	2026	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	12/9/2025	NON-COMPETING CONTINUATION	$477,398
														Subtotal = $477,398

Issue Date FY: 2025 ( Subtotal = $599,236 )
2025	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	5/19/2025	NON-COMPETING CONTINUATION	$59,924
2025	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	11/7/2024	NON-COMPETING CONTINUATION	$539,312
														Subtotal = $599,236

Issue Date FY: 2024 ( Subtotal = $618,792 )
2024	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	12/15/2023	NEW	$571,302
2024	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	6/6/2024	NEW	$47,490
														Subtotal = $618,792

Grand Total All Awards = $1,695,426

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Engineering pluripotent stem cells to evade and promote immunity

Award Number: R01EB035491

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/15/2023

PERIOD OF PERFORMANCE END DATE: 11/30/2027

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