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Advancing MRI with an open inhomogeneous B0 magnet

Award Number: R01EB035268
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Advancing MRI with an open inhomogeneous B0 magnet - Project Summary/Abstract The aim of this proposal is to enhance the technical development of an open MRI system that can be integrated into an exam table in a doctor's office, allowing MRI scans to be used similarly to ultrasound. This open-low-field MRI is silent and can produce high-quality images of any organ with the patient lying flat on the examination bed or standing for weighted spine or limb imaging with the device wall-mounted. Developing a small-footprint compact and low-cost MRI system allows MRI to be moved from hospitals to doctors' offices, with the impact that MRI could become more accessible to a wider population. This proposal combines developments in MR imaging with non-linear gradients, field-cycling MRI, spatial encoding using RF, and non-Fourier based algebraic reconstruction techniques incorporating parallel imaging. The objective is to enhance the image quality through innovative developments in both spatial encoding and pulse sequences. The preliminary data indicates strong signal, prolonged T2s, and exceptional image quality. Aims 1 and 2 integrate and optimize new encoding developments through novel RF coil designs, stop-motion imaging, and the introduction of gradient encoding to the system. The goal of these studies is to optimize resolution across the targeted volume (24x24x20cm). The proposal also introduces new pulse sequences with an emphasis on fat/water separation and quantification. Aim 3 tests three forms of fat-water contrast manipulation and gathers preliminary data on the effectiveness of this device for assessing fatty liver disease in both lean and obese subjects. Together, these aims will establish the imaging capabilities of the device, which would be a significant step forward on the path to improved accessibility. This proposal is innovative as it combines several proven technologies in novel ways to develop a new class of low-cost MRI devices that operate in inhomogeneous B0 fields.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	1/9/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $585,213 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	6/25/2025	NON-COMPETING CONTINUATION	$58,521
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	3/20/2025	NON-COMPETING CONTINUATION	$526,692
														Subtotal = $585,213

Issue Date FY: 2024 ( Subtotal = $571,562 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	6/26/2024	NEW	$571,562
														Subtotal = $571,562

Grand Total All Awards = $1,156,775

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Advancing MRI with an open inhomogeneous B0 magnet

Award Number: R01EB035268

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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