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A Novel Spray-On Sensing Platform Technology that Enables Wearable Visual Monitoring of Physiological Data and Environmental Exposure

Award Number: R01EB033913
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2025
AWARD TERMINATION DATE: 04/25/2025

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A Novel Spray-On Sensing Platform Technology that Enables Wearable Visual Monitoring of Physiological Data and Environmental Exposure - Abstract Wearable sensing has the potential to transform health care by alerting users about important information regarding their health and potential exposure to environmental risks. Some of the most critical barriers to wearable sensing include the cost, complexity, and reliability. Addressing the first two challenges is particularly important to prevent exacerbation of a digital divide in health between those who have access to technologies and the digital literacy to work them and those that do not. A widely deployable sensing platform technology for improving health and wellness that can equitably reach the population is thus needed. Past successes in point- of-care and at-home sensing, including lateral flow sensors, have demonstrated that simple, robust designs that are customizable to different targets can provide significant value and high reliability without the need for electronic systems. With that motivation, we are developing a spray-on sensor technology to serve as a platform for custom wearable coatings that can be easily interpreted by a color change upon exposure to tailored target stimuli. Our encouraging results recently demonstrated a set of proof-of-concept spray-on sensors formulated with diacetylene-containing amphiphiles that could detect physical stimuli (UV radiation) and different chemical targets depending on the amphiphile head-group chemistry. In the proposed project, we are initiating an iterative development approach to understand and enhance the safety and efficacy of our spray-on sensing formulations. In Aim 1, we will focus our efforts on assessing and improving the mechanical properties of our spray-on coating formulations for improved resistance to abrasion and washing without impacting their target sensitivity. Success of this aim will result in a robust coating that can provided reliable sensing throughout conditions experience in routine daily use. In order to provide an understanding of the biocompatibility of distinct formulations that are to be applied directly to the skin for sweat analysis, in Aim 2 we will conduct multiple complementary tests for skin irritation, permeation, and induction of adverse outcome pathways of skin sensitization. Through this aim we will be able to effectively make risk assessments in order to define appropriate exposure limits and if necessary utilize alternative formulation strategies for any components of concern. In Aim 3 with the dual intention of demonstrating the efficacy and reliability of our spray-on approach for different sensing applications, we will examine distinct spray-on formulations with tailored functional head-group chemistry of the diacetylene- amphiphiles for implementation of sweat analysis for lead poisoning, breath analysis for acetone (ketosis), and UV exposure for radiation dosimetry. These three sensor formulations will operate by applying the distinct spray coating onto the skin, onto a surgical mask, or onto fabric (clothing), respectively. By tuning the sensitivity, dynamic range, and selectivity of the individual spray-on sensor formulations for their specified target of interest, these studies will establish this as a novel platform technology for generating spray-on wearable coatings that are capable of reliably monitoring information important to understanding health and environmental exposure.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$31,277 )
2026	2024	UNIVERSITY OF TEXAS AT ARLINGTON	701 S NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	1/22/2026	TERMINATION	-$31,277
														Subtotal = -$31,277

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF TEXAS AT ARLINGTON	701 S NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	4/25/2025	TERMINATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $256,876 )
2024	2024	UNIVERSITY OF TEXAS AT ARLINGTON	701 S NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	5/21/2024	NON-COMPETING CONTINUATION	$256,876
														Subtotal = $256,876

Issue Date FY: 2023 ( Subtotal = $261,838 )
2023	2023	THE UNIVERSITY OF TEXAS AT ARLINGTON	701 S. NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	4/21/2023	NEW	$261,838
														Subtotal = $261,838

Grand Total All Awards = $487,437

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A Novel Spray-On Sensing Platform Technology that Enables Wearable Visual Monitoring of Physiological Data and Environmental Exposure

Award Number: R01EB033913

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2025

AWARD TERMINATION DATE: 04/25/2025

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