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A Rational Engineering Design Approach to Minimizing the Off-Target Effects of Baroreceptor Activation Therapy

Award Number: R01EB033403
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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A Rational Engineering Design Approach to Minimizing the Off-Target Effects of Baroreceptor Activation Therapy - Abstract Despite improvements in medical management, hypertension still affects >25% of adults, and 20 to 30% of them are resistant to pharmacological treatment. Similarly, heart failure patients with reduced ejection fraction continue to exhibit dramatically reduced life expectancy, frequent hospitalization, and overall poor quality of life. Chronic electrical stimulation of the baroreflex at the carotid sinus—known as baroreflex activation therapy (BAT)—is FDA-approved to mitigate the marked sympathetic activation associated with both hypertension and heart failure. BAT was demonstrated in multiple controlled clinical trials to produce sustained significant improvements in both hypertension and heart failure outcomes in patients non-responsive to traditional medical management; however, the therapy is limited by side effects. We propose an integrated approach to mitigate side effects and thereby improve the therapeutic efficacy of BAT. We seek to determine the functional neuroanatomy responsible for the side effects of BAT and to use these data to design and test approaches for more effective BAT neural interfaces. These optimized designs will expand the therapeutic window between baroreceptor activation and limiting off-target effects. The outcomes of this project will produce an optimized BAT interface design that could be quickly translated to address a clear clinical need. In addition, we will provide a needed framework for incorporation of local neural and tissue anatomy—which govern therapy-limiting side effects—into the neural interface design process that can be readily applied to myriad neuromodulation therapy targets.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $556,028 )
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	3/20/2025	NON-COMPETING CONTINUATION	$556,028
														Subtotal = $556,028

Issue Date FY: 2024 ( Subtotal = $611,927 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	6/25/2024	NON-COMPETING CONTINUATION	$49,951
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	3/13/2024	NON-COMPETING CONTINUATION	$561,976
														Subtotal = $611,927

Issue Date FY: 2023 ( Subtotal = $624,416 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	4/3/2023	NON-COMPETING CONTINUATION	$624,416
														Subtotal = $624,416

Issue Date FY: 2022 ( Subtotal = $663,655 )
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	6/24/2022	NEW	$663,655
														Subtotal = $663,655

Grand Total All Awards = $2,456,026

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A Rational Engineering Design Approach to Minimizing the Off-Target Effects of Baroreceptor Activation Therapy

Award Number: R01EB033403

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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