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Rationally Designed, Target-specific Imaging Probes for Nephro-urology Diagnoses

Award Number: R01EB033377
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2023
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Rationally Designed, Target-specific Imaging Probes for Nephro-urology Diagnoses - Project Title: Rationally Designed, Target-specific Imaging Probes for Nephro-urology Diagnoses Project Summary The project focuses on novel design and testing of kidney-specific probes for radionuclide renal imaging. Unlike existing standard-of-care tracers used in the clinic that rely on passive uptake and clearance mechanisms, our recombinant probes are based on targeted design for mapping kidney functions, including filtration at the glomerulus and protein sorting at the proximal tubule. This approach enables functional renal imaging with molecular specificity. We adapted a fusion strategy in designing the probes, in which we joined modular segments of selected plasma proteins to form new hybrid probes. These modular segments are the functional units that can individually interact with their cognate renal receptors. Accordingly, it is anticipated that each probe will follow a guided intrarenal passage and sequentially interactions with intended receptors. This novel approach holds promise, as demonstrated in proof-of-concept studies and will continue to be pursued, for measuring distinct functions of the kidney. We will accomplish our research goal via three interconnected and synergistic Specific Aims, which are designed for measuring critical aspects of the renal function and pathophysiology, including glomerular filtration and tubular reuptake (Aim 1), glomerular density (Aim 2), and the early pathological changes in the filtration barrier (Aim 3). The studies will be conducted in acute and chronic settings as appropriate using relevant kidney disease models such as ischemic/reperfusion injury, nephrotoxicity, hypertension and autoimmunity, which are representative of common renal diseases in humans. Overall, our new probes are intended for directly addressing the needs for early and specific markers of renal diseases. The imaging data from these probes will provide important mechanistic insights for advancing the technologies toward their ultimate translation to patient care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $463,388 )
2026	2026	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	1/30/2026	NON-COMPETING CONTINUATION	$463,388
														Subtotal = $463,388

Issue Date FY: 2025 ( Subtotal = $579,236 )
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	3	8/22/2025	NON-COMPETING CONTINUATION	$57,924
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	3/26/2025	NON-COMPETING CONTINUATION	$521,312
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	3/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $579,236

Issue Date FY: 2024 ( Subtotal = $565,566 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	5/8/2024	NON-COMPETING CONTINUATION	$565,566
														Subtotal = $565,566

Issue Date FY: 2023 ( Subtotal = $577,163 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	4/7/2023	NEW	$579,568
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	1	5/30/2023	NEW	-$2,405
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	4/12/2023	NEW	$0
														Subtotal = $577,163

Grand Total All Awards = $2,185,353

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Rationally Designed, Target-specific Imaging Probes for Nephro-urology Diagnoses

Award Number: R01EB033377

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2023

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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