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High-performance and cost-effective detector modules based on ultra-dense and fast ceramic scintillator for long axial field-of-view positron emission tomography

Award Number: R01EB030538
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2021
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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High-performance and cost-effective detector modules based on ultra-dense and fast ceramic scintillator for long axial field-of-view positron emission tomography - SUMMARY Positron emission tomography (PET) is unrivaled as a highly specific and sensitive means for tomographic imaging of molecular interactions and pathways in humans, offering great utility for translational medicine. Recently, long axial field-of-view PET scanners, which provide excellent geometric coverage, giving much better detection sensitivity, have been developed. However, cost and performance issues are raised as concerns. To resolve both cost and performance issues, next generation long axial field-of-view PET detector modules should employ new scintillators to realize the full performance capabilities of PET at a viable price point. A proposed ceramic scintillator has extremely high stopping power and density, better than any currently used scintillator for PET. The proposed scintillator has a high light yield and an excellent energy resolution. Moreover, we achieved a very good coincidence timing resolution. In addition, it has a cubic crystal structure allowing fabrication by ceramic processing, with potential for a major reduction in cost compared with L(Y)SO. This proposal is 1) to develop the new ceramic scintillator for PET with large volumes and high clarity, 2) to characterize the new scintillator as a PET scintillator, 3) to apply the new scintillator array blocks into well- designed existing PET detector modules to evaluate performance of the new scintillator at the module level, and finally 4) to develop novel time-of-flight (TOF)-PET detector modules by combining the new ceramic scintillator and advanced PET readout methods for next-generation PET scanners. The proposed ceramic scintillator and PET detector modules are not limited to long axial field-of-view PET scanners and will be widely usable. The impact of this proposal is that it provides a pathway to 1) realizing long axial field-of-view scanners with unprecedented sensitivity without a proportional increase in scanner cost and 2) enabling performance advantages in shorter scintillators in terms of reducing DOI effect and improving timing and energy resolution without losing detection efficiency for next-generation TOF-PET scanners.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $533,892 )
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	6/26/2024	NON-COMPETING CONTINUATION	$533,892
														Subtotal = $533,892

Issue Date FY: 2023 ( Subtotal = $556,077 )
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	7/31/2023	NON-COMPETING CONTINUATION	$556,077
														Subtotal = $556,077

Issue Date FY: 2022 ( Subtotal = $546,076 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	8/23/2022	NON-COMPETING CONTINUATION	$546,076
														Subtotal = $546,076

Issue Date FY: 2021 ( Subtotal = $546,512 )
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	8/24/2021	NEW	$546,512
														Subtotal = $546,512

Grand Total All Awards = $2,182,557

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High-performance and cost-effective detector modules based on ultra-dense and fast ceramic scintillator for long axial field-of-view positron emission tomography

Award Number: R01EB030538

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2021

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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