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Prism-PET: A TOF-DOI-Compton PET detector technology for total-body PET imaging

Award Number: R01EB030413
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2021
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Prism-PET: A TOF-DOI-Compton PET detector technology for total-body PET imaging - Abstract The relatively small axial field-of-view (FOV) in almost all PET scanners has severely limited their sensitivity and resulted in significant tradeoffs between image signal-to-noise ratio (SNR), acquisition time, and delivered dose. The solution is to improve geometric coverage using large axial FOV for total-body imaging which has the potential to improve sensitivity by about 40 times compared to existing commercial whole-body PET scanners. The construction of the world's first total-body PET/CT scan-ner, called EXPLORER, with 194-cm axial FOV has recently been completed. However, it has a poor time-of-flight (TOF) resolution of 430 ps, compared to the state-of-the-art whole-body PET scanner with 200 ps timing resolution (Siemens Biograph Vision). In addition, axial detector penetration of obliquely incident gamma photons detected within this wide acceptance angle will introduce significant depth-of-interaction (DOI) parallax error, leading to degraded spatial resolution. These two major defi-ciencies of the EXPLORER scanner offset its effective sensitivity gain, specially for imaging single organs such as the human brain when compared to the Biograph Vision PET scanner. For this research, we propose to build cost-effective block detectors with combined highest spatial resolution (2 mm), highest TOF resolution (<120 ps and potentially 100 ps), best DOI localization (1.85 mm), and highest inter- crystal Compton scatter recovery capabilities (88%) using single-ended readout and machine learning post-processing engines. Our novel detector module, called Prism-PET, enables these capabilities by mimicking very closely the behavior of dual-ended readout with enhanced and controlled light sharing using a segmented array of right angle prism-mirror light guides. Given our promising preliminary ex-perimental results, we aim to accomplish the following tasks: (1) model a prototype TOF-DOI PET scanner using GATE Monte Carlo simulations and use its list-mode data to develop our TOF-DOI image recontruction; (2) build Prism-PET detector modules and characterize coincidence detector blocks for DOI-corrected spatial resolution, energy resolution, and timing resolution and use machine learning to recover inter-crystal Compton scattered events to reach the 2-mm intrinsic spatial resolution without sacrificing sensitivity; (3) Build a one-ring prototype Prism-PET scanner; (4) perform normalization scan, optimize our image reconstruction using experimental coincidence events and validate the optimal imaging performance using Hot Spot phantoms. Our proposed TOF-DOI-Compton detector and system technologies maximize the sensitivity benefits of improved geometric coverage in total-body PET scanners across the entire FOV.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $576,992 )
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	5/6/2024	NON-COMPETING CONTINUATION	$576,992
2024	2023	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	3	9/11/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$195,830
2024	2022	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	9/11/2024	NON-COMPETING CONTINUATION	-$195,830
														Subtotal = $576,992

Issue Date FY: 2023 ( Subtotal = $644,704 )
2023	2023	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	6/15/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$644,704
2023	2022	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	6/14/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $644,704

Issue Date FY: 2022 ( Subtotal = $616,304 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	3/10/2022	NON-COMPETING CONTINUATION	$554,675
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	7/11/2022	NON-COMPETING CONTINUATION	$61,629
														Subtotal = $616,304

Issue Date FY: 2021 ( Subtotal = $647,165 )
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	4/16/2021	NEW	$647,165
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	5/25/2021	NEW	$0
														Subtotal = $647,165

Grand Total All Awards = $2,485,165

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Prism-PET: A TOF-DOI-Compton PET detector technology for total-body PET imaging

Award Number: R01EB030413

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2021

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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