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Personalized Management of Intracranial Aneurysms Using Computer-aided Analytics

Award Number: R01EB029570
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/07/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Personalized Management of Intracranial Aneurysms Using Computer-aided Analytics - Abstract The primary objective is to develop an artificial intelligence-centric, quantitative and noninvasive software platform that can be integrated into 3D angiographic scanners (DSA, CTA or MRA) to provide guidance regarding the diagnosis and management of intracranial aneurysms (IA). Hemorrhagic stroke secondary to ruptured IAs leads to significant morbidity and mortality and affects over 35,000 patients on a yearly basis in the United States. The diagnosis of asymptomatic IAs is on the rise with the increasing use of cerebral imaging. However, guidance regarding which aneurysms should be treated has not advanced. Leveraging recent advances in computational science and technology, particularly artificial intelligence, the proposed software platform built on two enabling technologies can (1) propel automated “patient-specific” hemodynamic evaluations into the clinical workflow and (2) conduct “data-driven” risk assessments of IA rupture on an individual basis. Specific research aims are to (1) develop a clinically-oriented CFD platform that enables automated “patient-specific” hemodynamic evaluations of IAs, (2) investigate data-driven analytics toward prediction of rupture risk for IAs and (3) evaluate the data-driven analytics in a blind study. Once validated, a follow-up R01 project is planned to examine the clinical utility of the proposed software platform in a prospective clinical study as a single gateway for computer-aided evaluation of cerebral aneurysms.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	MICHIGAN TECHNOLOGICAL UNIVERSITY	1400 TOWNSEND DR	HOUGHTON	MI	49931	HOUGHTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	2/19/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $326,853 )
2024	2024	MICHIGAN TECHNOLOGICAL UNIVERSITY	1400 TOWNSEND DR	HOUGHTON	MI	49931	HOUGHTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	1/4/2024	NON-COMPETING CONTINUATION	$300,172
2024	2024	MICHIGAN TECHNOLOGICAL UNIVERSITY	1400 TOWNSEND DR	HOUGHTON	MI	49931	HOUGHTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	6/26/2024	NON-COMPETING CONTINUATION	$26,681
														Subtotal = $326,853

Issue Date FY: 2023 ( Subtotal = $334,056 )
2023	2023	MICHIGAN TECHNOLOGICAL UNIVERSITY	1400 TOWNSEND DR	HOUGHTON	MI	49931	HOUGHTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	1/25/2023	NON-COMPETING CONTINUATION	$334,056
														Subtotal = $334,056

Issue Date FY: 2022 ( Subtotal = $334,560 )
2022	2022	MICHIGAN TECHNOLOGICAL UNIVERSITY	1400 TOWNSEND DR	HOUGHTON	MI	49931	HOUGHTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	2/25/2022	NON-COMPETING CONTINUATION	$301,103
2022	2022	MICHIGAN TECHNOLOGICAL UNIVERSITY	1400 TOWNSEND DR	HOUGHTON	MI	49931	HOUGHTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	6/30/2022	NON-COMPETING CONTINUATION	$33,457
														Subtotal = $334,560

Issue Date FY: 2021 ( Subtotal = $346,966 )
2021	2021	MICHIGAN TECHNOLOGICAL UNIVERSITY	1400 TOWNSEND DR	HOUGHTON	MI	49931	HOUGHTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	5/26/2021	NEW	$0
2021	2021	MICHIGAN TECHNOLOGICAL UNIVERSITY	1400 TOWNSEND DR	HOUGHTON	MI	49931	HOUGHTON	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	4/5/2021	NEW	$346,966
														Subtotal = $346,966

Grand Total All Awards = $1,342,435

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Personalized Management of Intracranial Aneurysms Using Computer-aided Analytics

Award Number: R01EB029570

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/07/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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